Evidence map›Paper›PMID 34277031›Full record

ArticleJournal of thoracic disease2021

Autologous blood patch pleurodesis for prolonged postoperative air leaks.

Irsa S Hasan, Mark S Allen, Stephen D Cassivi, William S Harmsen, Nandita Mahajan, Francis C Nichols, Janani Reisenauer, Robert K Shen, Dennis A Wigle, Shanda H Blackmon

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for the Treatment of Postoperative Air Leak After Lung Resections: A Prospective Randomized Controlled Study.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
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  7. New strategies in the management of pneumothorax.Breathe (Sheffield, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Irsa S HasanDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Mark S AllenDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Stephen D CassiviDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
William S HarmsenDepartment of Biostatistics, Mayo Clinic, Rochester, MN, USA.
Nandita MahajanDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Francis C NicholsDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Janani ReisenauerDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Robert K ShenDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Dennis A WigleDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Shanda H BlackmonDepartment of Surgery, Division of Thoracic Surgery, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA prolonged air leak (PAL) is the most frequent complication after pulmonary resection. This study aimed to assess the safety and efficacy of autologous blood patch pleurodesis (ABPP) to treat PAL.

methodsA prospectively maintained database identified patients with a PAL after pulmonary resection for lung cancer between 2015-2019. In this observational cohort study, clinical data were collected to retrospectively compare patients undergoing ABPP to no ABPP in a propensity-matched analysis. Kaplan Meier estimates and Cox models accounting for inverse probability weighting (IPTW) were used to assess the association of ABPP with each outcome.

resultsOf the 740 patients undergoing lung resection, 110 (15%) were identified as having a PAL at postoperative day (POD) 5. There was no difference between baseline characteristics among those undergoing ABPP (n=34) versus no ABPP (n=76). Propensity-weighted analysis did not reveal a significant association of ABPP treatment with in-hospital complication (P=0.18), hospital length of stay (LOS) (P=0.13), or post-discharge complication (P=0.13). However, ABPP treatment was associated with a lower risk of hospital readmission [P=0.02, hazard ratio (HR) 0.16] and reoperation for air leak or empyema (P=0.05, HR 0.11). Although not statistically significant, the mean chest tube (CT) removal of 11 days for the ABPP group was less than the no ABPP group (16 days) (P=0.14, HR 1.5-2). Those treated with ABPP were less likely to be discharged with a CT (ABPP 7/34, 21%

conclusionsABPP administration is safe compared to traditional PAL management. In a retrospective propensity-matched analysis, postoperative patients treated with ABPP required less readmission and reoperation for PAL. Larger powered randomized trials may demonstrate the magnitude of benefit from treatment with ABPP.

Indexed as

blood patchchest tubePleurodesisprolonged air leak (PAL)

Identifiers

PMID34277031
PMCPMC8264717
OpenAlexW3157653636

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.