Evidence map›Paper›PMID 34277016›Full record

ReviewNeuro-oncology practice2021

Paraneoplastic neurological syndrome: an evolving story.

Jiraporn Jitprapaikulsan, Pritikanta Paul, Smathorn Thakolwiboon, Shivam Om Mittal, Sean J Pittock, Divyanshu Dubey

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuro-oncology practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Jiraporn JitprapaikulsanDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Pritikanta PaulDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Smathorn ThakolwiboonDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Shivam Om MittalDepartment of Neurology, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE.
Sean J PittockDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Divyanshu DubeyDepartment of Neurology, Mayo Clinic, Rochester, Minnesota.
Mayo Clinic · USCleveland Clinic · USMahidol University · THSiriraj Hospital · THUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraneoplastic neurological syndrome (PNS) comprises a group of neurological disorders that result from a misguided immune response to the nervous system triggered by a distant tumor. These disorders frequently manifest before the diagnosis of the underlying neoplasm. Since the first reported case in 1888 by Oppenheim, the knowledge in this area has evolved rapidly. Several classic PNS have been described, such as limbic encephalitis, paraneoplastic cerebellar degeneration, encephalomyelitis, opsoclonus-myoclonus, sensory neuronopathy, Lambert-Eaton Myasthenic syndrome, and chronic gastrointestinal dysmotility. It is now recognized that PNS can have varied nonclassical manifestations that extend beyond the traditional syndromic descriptions. Multiple onconeural antibodies with high specificity for certain tumor types and neurological phenotypes have been discovered over the past 3 decades. Increasing use of immune checkpoint inhibitors (ICIs) has led to increased recognition of neurologic ICI-related adverse events. Some of these resemble PNS. In this article, we review the clinical, oncologic, and immunopathogenic associations of PNS.

Indexed as

autoimmune neurological syndromeimmune checkpoint inhibitorparaneoplastic neurological syndrome

Identifiers

PMID34277016
PMCPMC8278353
OpenAlexW3129398928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.