Evidence map›Paper›PMID 34276945›Full record

ArticleChemical science2021

A dual-caged resorufin probe for rapid screening of infections resistant to lactam antibiotics.

Jinghang Xie, Ran Mu, Mingxi Fang, Yunfeng Cheng, Fiona Senchyna, Angel Moreno, Niaz Banaei, Jianghong Rao

Abstract read
In one paragraph

Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Exploring antibiotic resistance with chemical tools.Chemical communications (Cambridge, England) · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinghang XieDepartments of Radiology and Chemistry, Molecular Imaging Program at Stanford, Stanford University School of Medicine Stanford CA 94305 USA jrao@stanford.edu.ORCID https://orcid.org/0000-0003-0894-5765
Ran MuDepartments of Radiology and Chemistry, Molecular Imaging Program at Stanford, Stanford University School of Medicine Stanford CA 94305 USA jrao@stanford.edu.
Mingxi FangDepartments of Radiology and Chemistry, Molecular Imaging Program at Stanford, Stanford University School of Medicine Stanford CA 94305 USA jrao@stanford.edu.
Yunfeng ChengDepartments of Radiology and Chemistry, Molecular Imaging Program at Stanford, Stanford University School of Medicine Stanford CA 94305 USA jrao@stanford.edu.
Fiona SenchynaDepartment of Pathology, Stanford University School of Medicine Stanford CA 94305 USA.
Angel MorenoDepartment of Pathology, Stanford University School of Medicine Stanford CA 94305 USA.
Niaz BanaeiDepartment of Pathology, Stanford University School of Medicine Stanford CA 94305 USA.
Jianghong RaoDepartments of Radiology and Chemistry, Molecular Imaging Program at Stanford, Stanford University School of Medicine Stanford CA 94305 USA jrao@stanford.edu.ORCID https://orcid.org/0000-0002-5143-9529

Funding

Beta-lactamase fluorescent probes for bacterial detectionR01AI125286 · NIAID · STANFORD UNIVERSITY · PI RAO, JIANGHONG · 2017 to 2020
$2.4M
NIAID NIH HHS R01 AI125286
6 · The paper itself

Abstract

The alarming increase of antimicrobial resistance urges rapid diagnosis and pathogen specific infection management. This work reports a rapid screening assay for pathogenic bacteria resistant to lactam antibiotics. We designed a fluorogenic N-cephalosporin caged 3,7-diesterphenoxazine probe CDA that requires sequential activations to become fluorescent resorufin. A series of studies with recombinant β-lactamases and clinically prevalent pathogens including

Identifiers

PMID34276945
PMCPMC8261730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.