ArticleChemical science2021
Flow electrochemistry: a safe tool for fluorine chemistry.
Article in Chemical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Metal-free molecular editing of indole via tandem reaction: Access to 2-aryl-3-aryldiazenylindole for theranostic applications.iScience · 2025Article
- Electrolyte-Controlled Regiodivergent Continuous Flow Electroselenocyclisations.Angewandte Chemie (International ed. in English) · 2025Article
- Non-Aqueous Binary and TernaryJournal of the American Chemical Society · 2025Article
- Electrochemical Trifluoromethylation of Enamides under Microflow Conditions.Organic process research & development · 2024Article
- Recent Progress in Synthetic Applications of Hypervalent Iodine(III) Reagents.Chemical reviews · 2024Review
- Automation and machine learning augmented by large language models in a catalysis study.Chemical science · 2024Review
- Electrocatalytic continuous flow chlorinations with iodine(I/III) mediators.Nature communications · 2024Article
- Flow Chemistry for Synthesis of 2-(C-Glycosyl)acetates from Pyranoses via Tandem Wittig and Michael Reactions.Organic process research & development · 2024Article
- Benzylic C(spBeilstein journal of organic chemistry · 2024Review
- Monofluoromethylation ofInternational journal of molecular sciences · 2023Review
- Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode.International journal of molecular sciences · 2023Article
- Two-step continuous-flow synthesis of 6-membered cyclic iodonium salts via anodic oxidation.Beilstein journal of organic chemistry · 2023Article
- Article
- Para-Fluorination of Anilides Using Electrochemically Generated Hypervalent Iodoarenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Recent Updates on Electrogenerated Hypervalent Iodine Derivatives and Their Applications as Mediators in Organic Electrosynthesis.Frontiers in chemistry · 2022Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heightened activity of compounds containing fluorine, especially in the field of pharmaceuticals, provides major impetus for the development of new fluorination procedures. A scalable, versatile, and safe electrochemical fluorination protocol is conferred. The strategy proceeds through a transient (difluoroiodo)arene, generated by anodic oxidation of an iodoarene mediator. Even the isolation of iodine(iii) difluorides was facile since electrolysis was performed in the absence of other reagents. A broad range of hypervalent iodine mediated reactions were achieved in high yields by coupling the electrolysis step with downstream reactions in flow, surpassing limitations of batch chemistry. (Difluoroiodo)arenes are toxic and suffer from chemical instability, so the uninterrupted generation and immediate use in flow is highly advantageous. High flow rates facilitated productivities of up to 834 mg h
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.