ArticleJournal of radiology case reports2021
Acute soft head syndrome in a sickle cell disease patient.
Article in Journal of radiology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- A rare and underrecognized complication of sickle cell disease in a pediatric patient: acute soft head syndrome.Emergency radiology · 2026Article
- Acute Soft Head Syndrome, A Rare Complication of Sickle Cell Anemia: A Case Report.Clinical case reports · 2026Article
- Acute Soft Head Syndrome: A Case Report in Kuwait and a Clinical Framework for Management.Cureus · 2025Article
- Diagnostic Overshadowing and the Unseen Spectrum: A Narrative Review of Rare Complications in Sickle Cell Disease.Clinics and practice · 2025Review
- Acute soft head syndrome and orbital compression syndrome in a child with sickle cell disease: a case report.Journal of medical case reports · 2025Article
- Acute soft head syndrome in sickle cell disease: A rare and under-recognized complication with diagnostic challenges.Radiology case reports · 2025Article
- Unilateral Facial Swelling in a Sickle Cell Patient.Cureus · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute soft head syndrome is an extremely rare complication in children with sickle cell anemia. We present a 16-year old male patient known to have sickle cell anemia who presented to our emergency department with low grade fever, headache, skull pain and swelling. Magnetic Resonance of the brain was done demonstrating subgaleal collections overlying calvarial signal abnormalities. The combination of clinical and radiological findings were indicative of acute soft head syndrome. Acute soft head syndrome is a rare complication in children with sickle cell anemia and the pathophysiology is related to osteonecrosis and bone infarcts of the calvarium as well as secondary reactive sub-galeal collections. Treatment includes conservative management with intravenous fluids and analgesics, in addition, our patient was treated with antibiotics since differentiation clinically and by imaging can be challenging. Acute soft head syndrome should be considered in the differential diagnosis of headache and skull swelling in children with sickle cell anemia.
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