Evidence map›Paper›PMID 34276695›Full record

ArticleFrontiers in immunology2021

PPE38-Secretion-Dependent Proteins of

James Gallant, Tiaan Heunis, Caroline Beltran, Karin Schildermans, Sven Bruijns, Inge Mertens, Wilbert Bitter, Samantha L Sampson

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Loss of the ESX-5 secretion locus inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. TheInternational journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

James GallantDepartment of Science and Technology/National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Tiaan HeunisDepartment of Science and Technology/National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Caroline BeltranDepartment of Science and Technology/National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Karin SchildermansHealth Unit, VITO, Antwerp, Belgium.
Sven BruijnsDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam Infection and Immunity Institute, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Inge MertensHealth Unit, VITO, Antwerp, Belgium.
Wilbert BitterSection Molecular Microbiology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Samantha L SampsonDepartment of Science and Technology/National Research Foundation Centre of Excellence in Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Province of Antwerp · BESouth African Medical Research Council · ZAVrije Universiteit Amsterdam · NLStellenbosch University · ZAUniversity of Oxford · GB

Funding

Medical Research Council MR/P028071/1
6 · The paper itself

Abstract

It was previously shown that secretion of PE-PGRS and PPE-MPTR proteins is abolished in clinical

Indexed as

Antigens, BacterialHumansInflammationMacrophagesMycobacterium tuberculosisNF-kappa BSignal TransductionTHP-1 CellsTuberculosisVirulenceVirulence FactorsAntigens, BacterialNF-kappa BVirulence FactorsmacrophageMycobacterium tuberculosisNF-KB signallingPE/PPEproteomics

Identifiers

PMID34276695
PMCPMC8284050
OpenAlexW3183786879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.