Evidence map›Paper›PMID 34276684›Full record

ArticleFrontiers in immunology2021

Prognostic Value of Tumor-Infiltrating Lymphocytes and Tertiary Lymphoid Structures in Epstein-Barr Virus-Associated and -Negative Gastric Carcinoma.

Na Cheng, Peng Li, Huanhuan Cheng, Xiaoxiao Zhao, Min Dong, Yiwang Zhang, Peizhen Zhao, Jianning Chen, Chunkui Shao

Open access · goldAbstract readComparative StudyMulticenter StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 7 pooled it
2.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 7 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  18. Tertiary lymphoid structures and their therapeutic implications in cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Na ChengDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Peng LiDepartment of Histology and Embryology of Basic Medical Department, Guangdong Medical University, Dongguan, China.
Huanhuan ChengDepartment of Ophthalmology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Xiaoxiao ZhaoDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Min DongDepartment of Medical Oncology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Yiwang ZhangDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Peizhen ZhaoDermatology Hospital, Southern Medical University, Guangzhou, China.
Jianning ChenDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Chunkui ShaoDepartment of Pathology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Third Affiliated Hospital of Sun Yat-sen University · CNSun Yat-sen University · CNGuangdong Medical College · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tumor-infiltrating lymphocytes (TILs) are considered a manifestation of the host immune response against cancer and tertiary lymphoid structures (TLS) may contribute to lymphocytes recruitment. Both of them have been reported as potential prognostic parameters in some human malignancies. However, the roles of TILs, TLS, and their correlation in Epstein-Barr Virus-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC) are largely unknown. Methods: To observe the correlation among TILs, TLS, and clinicopathological characteristics and their prognostic significance in EBVaGC and EBVnGC, respectively. TILs and TLS were assessed by morphology and/or immunohistochemistry, and accompanied by clinicopathological analysis from 846 gastric cancer patients in multiple institutions. Results: Forty-two (5.0%) cases of EBVaGC and 804 cases of EBVnGC were identified by Conclusion: TILs and TLS, especially TILs & TLS were promising prognostic indicators for overall survival in EBVnGC. TILs and TLS were highly overlapping in their extent and prognostic abilities, and may be considered as a coindicator of prognosis of gastric cancer. The evaluations of TILs and TLS are simple and can be assessed routinely in pathological diagnosis.

Indexed as

Decision Support TechniquesNomogramsCarcinomaChinaFemaleHerpesvirus 4, HumanHost-Pathogen InteractionsHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedPredictive Value of TestsPrognosisReproducibility of ResultsRisk AssessmentRisk FactorsEBV-associated gastric carcinomaEBV-negative gastric carcinomanomogramprognosistertiary lymphoid structurestumor-infiltrating lymphocytes

Identifiers

PMID34276684
PMCPMC8281029
OpenAlexW3184050310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.