Evidence map›Paper›PMID 34276682›Full record

ArticleFrontiers in immunology2021

Regulatory B Cells (Bregs) Inhibit Osteoclastogenesis and Play a Potential Role in Ameliorating Ovariectomy-Induced Bone Loss.

Leena Sapra, Asha Bhardwaj, Pradyumna Kumar Mishra, Bhavuk Garg, Bhupendra Verma, Gyan C Mishra, Rupesh K Srivastava

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 55 citations in OpenAlex.

  1. iScience · 2026
    Article
  2. Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
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  10. Gut microbes · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Leena SapraDepartment of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Asha BhardwajDepartment of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Pradyumna Kumar MishraDepartment of Molecular Biology, ICMR-National Institute for Research in Environmental Health, Bhopal, India.
Bhavuk GargDepartment of Orthopaedics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Bhupendra VermaDepartment of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Gyan C MishraNational Centre for Cell Science (NCCS), Pune, India.
Rupesh K SrivastavaDepartment of Biotechnology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
All India Institute of Medical Sciences · INDepartment of Biotechnology · INICMR National Institute for Research in Environmental HealthNational Centre for Cell Science · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence in recent years has suggested that regulatory B cells (Bregs) are one of the crucial modulators in various inflammatory disease conditions. However, no study to date has investigated the significance of Bregs in modulating osteoclastogenesis. To the best of our knowledge, in the present study, we for the first time examined the anti-osteoclastogenic potential of Bregs under

Indexed as

AnimalsB-Lymphocytes, RegulatoryCells, CulturedCoculture TechniquesDisease Models, AnimalFemaleHumansInterleukin-10MiceMice, Inbred C57BLOsteoclastsOsteogenesisOsteoporosis, PostmenopausalOvariectomySpleenInterleukin-10bone healthBregsosteoclastosteoporosisregulatory B cells

Identifiers

PMID34276682
PMCPMC8278221
OpenAlexW3175409385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.