Evidence map›Paper›PMID 34276643›Full record

ArticleFrontiers in immunology2021

Distinct Microbiomes of Gut and Saliva in Patients With Systemic Lupus Erythematous and Clinical Associations.

Fengping Liu, Tianli Ren, Xiaodi Li, Qixiao Zhai, Xifeng Xu, Nan Zhang, Peng Jiang, Yaofang Niu, Longxian Lv, GuoXun Shi and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Fengping LiuWuxi School of Medicine, Jiangnan University, Wuxi, China.
Tianli RenDepartment of Rheumatology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Xiaodi LiDepartment of Rheumatology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Qixiao ZhaiState Key Laboratory of Food Science and Technology and School of Food Science and Technology, Jiangnan University, Wuxi, China.
Xifeng XuDepartment of Outpatient, Wuxi Children's Hospital of Nanjing Medical University, Wuxi, China.
Nan ZhangDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Peng JiangDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Yaofang NiuResearch and Development Department, Hangzhou Guhe Information and Technology Company, Hangzhou, China.
Longxian LvCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
GuoXun ShiDepartment of Rheumatology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Ninghan FengDepartment of Urology, Affiliated Wuxi No. 2 Hospital, Nanjing Medical University, Wuxi, China.
Nanjing Medical University · CNWuxi No.2 People's Hospital · CNJiangnan University · CNWuxi People's Hospital · CNZhejiang Science and Technology Information Institute · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alterations in the microbiome of the gut and oral cavity are involved in the etiopathogenesis of systemic lupus erythematosus (SLE). We aimed to assess whether both microbiome compositions in feces and saliva were specific in patients with SLE. A total of 35 patients with SLE, as well as sex- and age-matched asymptomatic subjects as healthy control (HC) group were recruited. Fecal swabs and saliva samples were collected from the participants. 16S ribosomal RNA gene sequencing was performed on the samples. Compared with the HC group, reduced bacterial richness and diversity were detected in the feces of patients with SLE, and increased bacterial diversity in their saliva. Both feces and saliva samples explained the cohort variation. The feces were characterized by enrichment of

Indexed as

AdultAgedBacteriaCohort StudiesFecesFemaleGastrointestinal MicrobiomeGenetic VariationHumansLupus Erythematosus, SystemicMaleMicrobiotaMiddle AgedMouthSalivaYoung Adultcomplementdisease activityfecesmicrobiomesalivasystemic lupus erythematosus

Identifiers

PMID34276643
PMCPMC8281017
OpenAlexW3185558140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.