Evidence map›Paper›PMID 34276603›Full record

ArticleFrontiers in microbiology2021

Characterizing Expression and Regulation of Gamma-Herpesviral Circular RNAs.

Takanobu Tagawa, Daniel Oh, Jerico Santos, Sarah Dremel, Guruswamy Mahesh, Thomas S Uldrick, Robert Yarchoan, Vishal N Kopardé, Joseph M Ziegelbauer

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Roles and Applications of Circular RNA in Virus Infection.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. A virus-induced circular RNA maintains latent infection of Kaposi's sarcoma herpesvirus.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
  14. Review
  15. Identification and characterization of human cytomegalovirus-encoded circular RNAs.Frontiers in cellular and infection microbiology · 2022
    Article
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Takanobu TagawaHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
Daniel OhHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
Jerico SantosHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
Sarah DremelHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
Guruswamy MaheshHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
Thomas S UldrickHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
Robert YarchoanHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
Vishal N KopardéCCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Joseph M ZiegelbauerHIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD, United States.
National Cancer Institute · USNational Institutes of Health · USUniversity of the Philippines Manila · PH

Funding

Functions of KSHV microRNAs and circular RNAsZIABC011176 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ZIEGELBAUER, JOSEPH · 2009 to 2025
$14.0M
Virus host interactions in clinical samplesZIABC012047 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ZIEGELBAUER, JOSEPH · 2021 to 2025
$4.3M
Intramural NIH HHS ZIA BC011176
6 · The paper itself

Abstract

Multiple herpesviruses have been recently found to encode viral circular RNAs. Like cellular circular RNAs, these RNAs lack poly-A tails and their 5' and 3' ends have been joined, which confers protection from RNA exonucleases. We examined the expression patterns of circular RNAs from Kaposi's sarcoma herpesvirus (KSHV) in various environments. We performed deep sequencing of circRNA-enriched total RNA from a KSHV-positive patient lymph node for comparison with previous circRNA-Seq results. We found that circvIRF4 is highly expressed in the KSHV-positive patient sample relative to both B cell lines and

Indexed as

circular RNAEpstein–Barr virusKaposi sarcoma herpesvirusnon-coding RNAsprimary effusion lymphomaRNA binding protein

Identifiers

PMID34276603
PMCPMC8278476
OpenAlexW3177221809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.