Evidence map›Paper›PMID 34276592›Full record

ArticleFrontiers in microbiology2021

Screening of Compounds for Anti-tuberculosis Activity, and

Wei Zhou, Bing Yang, Yanyan Zou, Khaista Rahman, Xiaojian Cao, Yingying Lei, Ren Lai, Zhen F Fu, Xi Chen, Gang Cao

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  7. Screening of Microbial Fermentation Products for Anti-Animals : an open access journal from MDPI · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wei ZhouState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Bing YangState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yanyan ZouState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Khaista RahmanState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Xiaojian CaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Yingying LeiState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Ren LaiKey Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China.
Zhen F FuState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Xi ChenState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Gang CaoState Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China.
Huazhong Agricultural University · CNKunming Institute of Zoology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is a debilitating infectious disease responsible for more than one million deaths per year. The emergence of drug-resistant TB poses an urgent need for the development of new anti-TB drugs. In this study, we screened a library of over 4,000 small molecules and found that orbifloxacin and the peptide AK15 possess significant bactericidal activity against

Indexed as

combination therapyDNA gyrasedrug resistancemolecular dockingMycobacterium tuberculosisorbifloxacintuberculosis

Identifiers

PMID34276592
PMCPMC8278749
OpenAlexW3176192041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.