Evidence map›Paper›PMID 34276386›Full record

ArticleFrontiers in pharmacology2021

High Dose Lopinavir/Ritonavir Does Not Lead to Sufficient Plasma Levels to Inhibit SARS-CoV-2 in Hospitalized Patients With COVID-19.

Mario Karolyi, Sara Omid, Erich Pawelka, Bernd Jilma, Thomas Stimpfl, Christian Schoergenhofer, Hermann Laferl, Tamara Seitz, Marianna Traugott, Christoph Wenisch and 1 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Lopinavir/ritonavir for treatment of non-hospitalized patients with COVID-19: a randomized clinical trial.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Trial
  2. COVID-19 Therapeutic Potential of Natural Products.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mario KarolyiDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Sara OmidDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Erich PawelkaDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Bernd JilmaDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Thomas StimpflDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Christian SchoergenhoferDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Hermann LaferlDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Tamara SeitzDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Marianna TraugottDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Christoph WenischDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.
Alexander ZoufalyDepartment for Infectious Diseases and Tropical Medicine, Klinik Favoriten, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antiviralslopinavirplasma concentrationritonavirsevere COVID-19treatment

Identifiers

PMID34276386
PMCPMC8282360

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.