Evidence map›Paper›PMID 34276353›Full record

ReviewFrontiers in pharmacology2021

Protective Effects and Network Analysis of Ginsenoside Rb1 Against Cerebral Ischemia Injury: A Pharmacological Review.

Weijie Xie, Xinyue Wang, Tianbao Xiao, Yibo Cao, Yumei Wu, Dongsheng Yang, Song Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Weijie XieShanghai Mental Health Centre, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xinyue WangShanghai Mental Health Centre, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tianbao XiaoFirst Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Yibo CaoFirst Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Yumei WuSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Dongsheng YangSchool of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Song ZhangDepartment of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Affiliated Hospital of Guizhou Medical University · CNShanghai Mental Health Center · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a leading cause of death and disability worldwide. Currently, only a limited number of drugs are available for treating ischemic stroke. Hence, studies aiming to explore and develop other potential strategies and agents for preventing and treating ischemic stroke are urgently needed. Ginseng Rb1 (GRb1), a saponin from natural active ingredients derived from traditional Chinese medicine (TCM), exerts neuroprotective effects on the central nervous system (CNS). We conducted this review to explore and summarize the protective effects and mechanisms of GRb1 on cerebral ischemic injury, providing a valuable reference and insights for developing new agents to treat ischemic stroke. Our summarized results indicate that GRb1 exerts significant neuroprotective effects on cerebral ischemic injury both

Indexed as

antiapoptosisanti-inflammatoryantioxidantginsenoside Rb1ischemia and reperfusion injuryischemia stroke

Identifiers

PMID34276353
PMCPMC8283782
OpenAlexW3185543867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.