Evidence map›Paper›PMID 34276300›Full record

ArticleFrontiers in neuroscience2021

Partial mGlu

Kimberly M Holter, Alex D Lekander, Christina M LaValley, Elizabeth G Bedingham, Bethany E Pierce, L Paul Sands, Craig W Lindsley, Carrie K Jones, Robert W Gould

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Spontaneous daily sleep disruptions associated with morphine dependence and withdrawal in rats.The Journal of pharmacology and experimental therapeutics · 2025
    Article
  3. (R)-ketamine induces mGluPsychopharmacology · 2025
    Article
  4. Article
  5. Article
  6. NOP agonist AT-403 promoted sleep in lactic acid-induced acute pain model.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Article
  7. Review
  8. Partial mGluPharmacological reports : PR · 2024
    Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Kimberly M HolterDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Alex D LekanderDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Christina M LaValleyDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Elizabeth G BedinghamWake Forest University, Winston-Salem, NC, United States.
Bethany E PierceDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
L Paul SandsDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States.
Carrie K JonesDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States.
Robert W GouldDepartment of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, United States.
Wake Forest University · USVanderbilt University · USVanderbilt University Medical Center · US

Funding

Partial mGlu5 Negative Allosteric Modulators to Prevent Relapse to Cocaine AbuseR00DA042129 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI GOULD, ROBERT WARREN · 2019 to 2021
$747k
Partial mGlu5 Negative Allosteric Modulators to Prevent Relapse to Cocaine AbuseK99DA042129 · NIDA · VANDERBILT UNIVERSITY · PI GOULD, ROBERT WARREN · 2017 to 2018
$183k
Influence of Temporal Difference Reward Prediction Errors on Brain Network Connectivity during Learning and Decision-MakingF31DA053174 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SANDS, LESTER PAUL · 2021 to 2022
$70k
NIDA NIH HHS F31 DA053174NIDA NIH HHS K99 DA042129NIDA NIH HHS R00 DA042129
6 · The paper itself

Abstract

Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu

Indexed as

cognitionelectroencephalography (EEG)metabotropic glutamate receptor 5 (mGlu5)MK-801negative allosteric modulator (NAM)

Identifiers

PMID34276300
PMCPMC8283128
OpenAlexW3186101592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.