Evidence map›Paper›PMID 34276289›Full record

ArticleFrontiers in neuroscience2021

Determination of Diffusion Kinetics of Ketamine in Brain Tissue: Implications for

Zachary Geiger, Brett VanVeller, Zarin Lopez, Abdel K Harrata, Kathryn Battani, Lauren Wegman-Points, Li-Lian Yuan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Zachary GeigerDepartment of Physiology and Pharmacology, College of Osteopathic Medicine, Des Moines University, Des Moines, IA, United States.
Brett VanVellerDepartment of Chemistry, Iowa State University, Ames, IA, United States.
Zarin LopezDepartment of Physiology and Pharmacology, College of Osteopathic Medicine, Des Moines University, Des Moines, IA, United States.
Abdel K HarrataDepartment of Chemistry, Iowa State University, Ames, IA, United States.
Kathryn BattaniDepartment of Physiology and Pharmacology, College of Osteopathic Medicine, Des Moines University, Des Moines, IA, United States.
Lauren Wegman-PointsDepartment of Physiology and Pharmacology, College of Osteopathic Medicine, Des Moines University, Des Moines, IA, United States.
Li-Lian YuanDepartment of Physiology and Pharmacology, College of Osteopathic Medicine, Des Moines University, Des Moines, IA, United States.
Des Moines University · USIowa State University · US

Funding

Peptide backbone modifications to modulate peptide folding and functionR35GM142883 · NIGMS · IOWA STATE UNIVERSITY · PI Brett VanVeller · 2021 to 2026
$2.3M
Antidepressant Actions of Glutamatergic AgentsR15MH108043 · NIMH · DES MOINES UNIV OSTEOPATHIC MEDICAL CTR · PI YUAN, LILIAN · 2015 to 2015
$434k
NIGMS NIH HHS R35 GM142883NIMH NIH HHS R15 MH108043
6 · The paper itself

Abstract

Ketamine has been in use for over 50 years as a general anesthetic, acting primarily through blockade of

Indexed as

antidepressantbrainhippocampus sliceketamineNMDA receptorpharmacokineticssynaptic plasticity

Identifiers

PMID34276289
PMCPMC8280316
OpenAlexW3173891753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.