New Computational Approach for Peptide Vaccine Design Against SARS-COV-2.

Subhamoy Biswas, Smarajit Manna, Ashesh Nandy, Subhash C Basak

Open access · bronzeAbstract read

In one paragraph

Article in International journal of peptide research and therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 51% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

Combatting future variants of SARS-CoV-2 using an in-silico peptide vaccine approach by targeting the spike protein.Medical hypotheses · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Subhamoy BiswasDepartment of Electrical Engineering, Jadavpur University, Kolkata, 700032 India.ORCID 0000-0002-0055-4922

Smarajit MannaJagadis Bose National Science Talent Search, Kolkata, 700107 India.

Ashesh NandyCentre for Interdisciplinary Research and Education, Kolkata, 700068 India.

Subhash C BasakDepartment of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, Minnesota 55812 USA.

Centre for Interdisciplinary Research and Education · INJadavpur University · INUniversity of Minnesota, Duluth · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The design for vaccines using in silico analysis of genomic data of different viruses has taken many different paths, but lack of any precise computational approach has constrained them to alignment methods and some alignment-free techniques. In this work, a precise computational approach has been established wherein two new mathematical parameters have been suggested to identify the highly conserved and surface-exposed regions which are spread over a large region of the surface protein of the virus so that one can determine possible peptide vaccine candidates from those regions. The first parameter,

Indexed as

Alignment-free sequence analysisIn silico drug designPeptide vaccinesSARS-CoV-2Viral epidemics

Identifiers

PMID34276265

DOI10.1007/s10989-021-10251-7

PMCPMC8270779

OpenAlexW3179755529

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.