Evidence map›Paper›PMID 34276185›Full record

ReviewAnnals of gastroenterology

Alcohol consumption in patients with nonalcoholic fatty liver disease: yes, or no?

Adonis A Protopapas, Evangelos Cholongitas, Lampros Chrysavgis, Konstantinos Tziomalos

Open access · diamondAbstract readReview
In one paragraph

Review in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Adonis A ProtopapasFirst Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki (Adonis A. Protopapas, Konstantinos Tziomalos).
Evangelos CholongitasFirst Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens (Evangelos Cholongitas, Lampros Chrysavgis), Greece.
Lampros ChrysavgisFirst Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens (Evangelos Cholongitas, Lampros Chrysavgis), Greece.
Konstantinos TziomalosFirst Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki (Adonis A. Protopapas, Konstantinos Tziomalos).
Laiko General Hospital of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive alcohol intake is an established risk factor for chronic liver disease. At the same time, moderate alcohol intake appears to reduce cardiovascular morbidity. Accordingly, recommendations for alcohol intake in patients with nonalcoholic fatty liver disease (NAFLD), who are at increased risk for liver-related and cardiovascular events, are a point of debate. Some studies have shown beneficial effects of alcohol on cardiovascular and overall mortality in this specific subset of patients. Nonetheless, even light alcohol intake appears to aggravate liver disease and increase the risk of hepatocellular cancer. Therefore, patients with nonalcoholic steatohepatitis or advanced fibrosis should be advised against consuming alcohol. On the other hand, only light alcohol consumption (<10 g/day) might be permitted in patients without significant hepatic fibrosis, provided that they are carefully followed-up. As the research field focusing on NAFLD keeps widening, more prospective studies regarding this specific subject are expected, and may provide a basis for less ambiguous recommendations.

Indexed as

alcoholcardiovascular diseasefibrosishepatocellular cancerNonalcoholic fatty liver disease

Identifiers

PMID34276185
PMCPMC8276351
OpenAlexW3166917934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.