Evidence map›Paper›PMID 34276138›Full record

ArticleSensors and actuators. B, Chemical2018

Anti-biofouling implantable catheter using thin-film magnetic microactuators.

Qi Yang, Hyunsu Park, Tran N H Nguyen, Jeffrey F Rhoads, Albert Lee, R Timothy Bentley, Jack W Judy, Hyowon Lee

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi YangWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Hyunsu ParkWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Tran N H NguyenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Jeffrey F RhoadsBirck Nanotechnology Center, Purdue University, West Lafayette, IN 47907, USA.
Albert LeeGoodman Campbell Brain and Spine Department of Neurological Surgery Indiana University, Indianapolis, IN 46202, USA.
R Timothy BentleyCollege of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Jack W JudyDepartment of Electrical and Computer Engineering Nanoscience Institute for Medical and Engineering Technologies University of Florida, Gainesville, FL 32611, USA.
Hyowon LeeWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Funding

Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
In vivo evaluation of implantable self-clearing catheter for hydrocephalusR21NS095287 · NINDS · PURDUE UNIVERSITY · PI LEE, HYOWON · 2016 to 2017
$409k
MEMS-Enabled Ventricular Catheter for HydrocephalusR21NS062324 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BERGSNEIDER, MARVIN, JUDY, JACK W · 2009 to 2010
$388k
NCATS NIH HHS UL1 TR001108NINDS NIH HHS R21 NS062324NINDS NIH HHS R21 NS095287
6 · The paper itself

Abstract

Here we report on the development of polyimide-based flexible magnetic actuators for actively combating biofouling that occurs in many chronically implanted devices. The thin-film flexible devices are microfabricated and integrated into a single-pore silicone catheter to demonstrate a proof-of-concept for a self-clearing smart catheter. The static and dynamic mechanical responses of the thin-film magnetic microdevices were quantitatively measured and compared to theoretical values. The mechanical fatigue properties of these polyimide-based microdevices were also characterized up to 300 million cycles. Finally, the biofouling removal capabilities of magnetically powered microdevices were demonstrated using bovine serum albumin and bioconjugated microbeads. Our results indicate that these thin-film microdevices are capable of significantly reducing the amount of biofouling. At the same time, we demonstrated that these microdevices are mechanically robust enough to withstand a large number of actuation cycles during its chronic implantation.

Indexed as

BiofoulingImplantable microdeviceMagnetic microactuatorsPolyimideThin-film device

Identifiers

PMID34276138
PMCPMC8281922

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.