Evidence map›Paper›PMID 34275971›Full record

ArticleThe Journal of reproduction and development2021

Direct embryotoxicity of chromium (III) exposure during preimplantation development.

Yuhe Tian, Qisheng Zhu, Jiayu Yuan, Robert Kneepkens, Yuan Yue, Chao Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Yuhe TianHigh School Affiliated to Renmin University of China, Beijing, China.
Qisheng ZhuHigh School Affiliated to Renmin University of China, Beijing, China.
Jiayu YuanHigh School Affiliated to Renmin University of China, Beijing, China.
Robert KneepkensHigh School Affiliated to Renmin University of China, Beijing, China.
Yuan YueKey Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs; National Engineering Laboratory for Animal Breeding; College of Animal Science and Technology, China Agricultural University, Beijing, China.
Chao ZhangKey Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture and Rural Affairs; National Engineering Laboratory for Animal Breeding; College of Animal Science and Technology, China Agricultural University, Beijing, China.
Renmin University of China · CNChina Agricultural University · CNMinistry of Agriculture and Rural Affairs · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromium in its trivalent form (chromium (III)) is an essential component of a balanced diet, and its deficiency disturbs glucose and lipid metabolism in humans and animals. The prevailing view is that chromium (III) is notably less toxic than chromium (VI), which is genotoxic and carcinogenic. Thus, the biotransformation of environmental chromium (VI) to chromium (III) is a promising and environmentally friendly detoxification method. However, increasing evidence suggests that chromium (III) induces considerable cytotoxicity. However, the toxicity of chromium (III) to early embryos remains largely unknown. In the present study, we used in vitro fertilization (IVF) to produce mouse embryos and identified the direct embryotoxicity of chromium (III). On exposure to high concentrations of CrCl

Indexed as

AnimalsApoptosisBlastocystChloridesChromiumChromium CompoundsDose-Response Relationship, DrugEmbryonic DevelopmentFemaleFertilization in VitroMaleMiceMice, Inbred ICROxidative StressTeratogensChloridesChromiumChromium Compoundschromous chlorideTeratogensApoptosisBlastocystsChromium (III)Mouse embryosToxicity

Identifiers

PMID34275971
PMCPMC8423605
OpenAlexW3184424238

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.