Evidence map›Paper›PMID 34275872›Full record

Trial reportBMJ global health2021

Comparison of community-led distribution of HIV self-tests kits with distribution by paid distributors: a cluster randomised trial in rural Zimbabwean communities.

Euphemia Lindelwe Sibanda, Collin Mangenah, Melissa Neuman, Mary Tumushime, Constancia Watadzaushe, Miriam N Mutseta, Galven Maringwa, Jeffrey Dirawo, Katherine L Fielding, Cheryl Johnson and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Euphemia Lindelwe SibandaCeSHHAR Zimbabwe, Harare, Zimbabwe euphemia@ceshhar.co.zw.ORCID 0000-0003-1754-1076
Collin MangenahCeSHHAR Zimbabwe, Harare, Zimbabwe.ORCID 0000-0002-0733-0622
Melissa NeumanDepartment of Infectious Disease Epidemiology and MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-8870-6504
Mary TumushimeCeSHHAR Zimbabwe, Harare, Zimbabwe.
Constancia WatadzausheCeSHHAR Zimbabwe, Harare, Zimbabwe.
Miriam N MutsetaDepartment of Sexual Reproductive Health Rights and Innovations, Population Services International Zimbabwe, Harare, Zimbabwe.
Galven MaringwaCeSHHAR Zimbabwe, Harare, Zimbabwe.
Jeffrey DirawoCeSHHAR Zimbabwe, Harare, Zimbabwe.
Katherine L FieldingDepartment of Infectious Disease Epidemiology and MRC International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-6524-3754
Cheryl JohnsonHIV, Hepatitis and STI Department, World Health Organisation, Geneva, Switzerland.ORCID 0000-0001-5499-5523
Getrude NcubeAIDS and TB Unit, Ministry of Health and Child Care, Harare, Zimbabwe.
Miriam TaegtmeyerDepartment of International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID 0000-0002-5377-2536
Karin HatzoldPopulation Services International, Washington, District of Columbia, USA.
Elizabeth Lucy CorbettDepartment of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-3552-3181
Fern Terris-PrestholtDepartment of Global Health & Development, Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0003-1693-5196
Frances M CowanCeSHHAR Zimbabwe, Harare, Zimbabwe.ORCID 0000-0003-3087-4422

Funding

Medical Research Council MR/R010161/1Medical Research Council MR/S005307/1Wellcome Trust 200901/Z/16/ZWellcome Trust WT200901/Z/16/ZWorld Health Organization 001
6 · The paper itself

Abstract

backgroundWe compared community-led versus an established community-based HIV self-testing (HIVST) model in rural Zimbabwe using a cluster-randomised trial.

methodsForty village groups were randomised 1:1 using restricted randomisation to community-led HIVST, where communities planned and implemented HIVST distribution for 4 weeks, or paid distribution (PD), where distributors were paid US$50 to distribute kits door-to-door over 4 weeks. Individual level primary outcomes compared household survey responses by arm 4 months post-intervention for: (1) newly diagnosed HIV during/within 4 months following HIVST distribution, (2) linkage to confirmatory testing, pre-exposure prophylaxis or voluntary medical male circumcision during/within 4 months following HIVST distribution. Participants were not masked to allocation; analysis used masked data. Trial analysis used random-effects logistic regression.Distribution costs compared: (1) community-led HIVST, (2) PD HIVST and (3) PD costs when first implemented in 2016/2017.

resultsFrom October 2018 to August 2019, 27 812 and 36 699 HIVST kits were distributed in community-led and PD communities, respectively. We surveyed 11 150 participants and 5683 were in community-led arm. New HIV diagnosis was reported by 211 (3.7%) community-led versus 197 (3.6%) PD arm participants, adjusted OR (aOR) 1.1 (95% CI 0.72 to 1.56); 318 (25.9%) community-led arm participants linked to post-test services versus 361 (23.9%) in PD arm, aOR 1.1 (95% CI 0.75 to 1.49.Cost per HIVST kit distributed was US$6.29 and US$10.25 for PD and community-led HIVST, both lower than 2016/2017 costs for newly implemented PD (US$14.52). No social harms were reported.

conclusionsCommunity-led HIVST can perform as well as paid distribution, with lower costs in the first year. These costs may reduce with programme maturity/learning. TRIAL REGISTRATION NUMBER: PACTR201811849455568.

Indexed as

HIV InfectionsMass ScreeningHumansMaleRural PopulationSelf-TestingSurveys and Questionnairescommunity-based surveyhealth economics

Identifiers

PMID34275872
PMCPMC8287604

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.