Evidence map›Paper›PMID 34275865›Full record

Trial reportBMJ global health2021

Community-based HIV self-testing: a cluster-randomised trial of supply-side financial incentives and time-trend analysis of linkage to antiretroviral therapy in Zimbabwe.

Euphemia Lindelwe Sibanda, Melissa Neuman, Mary Tumushime, Collin Mangenah, Karin Hatzold, Constancia Watadzaushe, Miriam N Mutseta, Jeffrey Dirawo, Sue Napierala, Getrude Ncube and 7 more

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMJ global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 4 countries.

Euphemia Lindelwe SibandaCeSHHAR Zimbabwe, Harare, Zimbabwe euphemia@ceshhar.co.zw.ORCID 0000-0003-1754-1076
Melissa NeumanMRC Tropical Epidemiology Group, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-8870-6504
Mary TumushimeCeSHHAR Zimbabwe, Harare, Zimbabwe.
Collin MangenahCeSHHAR Zimbabwe, Harare, Zimbabwe.ORCID 0000-0002-0733-0622
Karin HatzoldHIV and Tuberculosis, Population Services International Global, Washington, DC, USA.
Constancia WatadzausheCeSHHAR Zimbabwe, Harare, Zimbabwe.
Miriam N MutsetaDepartment of Sexual Reproductive Health Rights and Innovations, Population Services International Zimbabwe, Harare, Zimbabwe.
Jeffrey DirawoCeSHHAR Zimbabwe, Harare, Zimbabwe.
Sue NapieralaWomen's Global Health Imperative, RTI International, Berkeley, California, USA.
Getrude NcubeHIV and TB Unit, Ministry of Health and Child Care, Harare, Zimbabwe.
Fern Terris-PrestholtDepartment of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Miriam TaegtmeyerDepartment of International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK.
Cheryl JohnsonHIV Department, Geneva, Switzerland.
Katherine L FieldingDepartment of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Helen A WeissDepartment of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
Elizabeth CorbettDepartment of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Public Health, London, UK.
Frances M CowanCeSHHAR Zimbabwe, Harare, Zimbabwe.ORCID 0000-0003-3087-4422
Centre for Sexual Health and HIV AIDS Research · ZWLondon School of Hygiene & Tropical Medicine · GBLiverpool School of Tropical Medicine · GBMinistry of Health and Child Welfare · ZWPopulation Services International · USRTI International · USUniversity of Liverpool · GB

Funding

Medical Research Council MR/R010161/1Medical Research Council MR/S005307/1Wellcome Trust 200901/Z/16/ZWellcome Trust WT200901/Z/16/Z
6 · The paper itself

Abstract

backgroundHIV self-testing (HIVST) requires linkage to post-test services to maximise its benefits. We evaluated effect of supply-side incentivisation on linkage following community-based HIVST and evaluated time-trends in facility-based antiretroviral therapy (ART) initiations.

methodsFrom August 2016 to August 2017 community-based distributors (CBDs) in 38 rural Zimbabwean communities distributed HIVST door-to-door in 19-25 day campaigns. Communities were allocated (1:1) using constrained randomisation to either one-off US$50 remuneration per CBD (non-incentive arm), or US$50 plus US$0.20 incentive per client visiting mobile-outreach services (conditional-incentive arm). The primary outcome, assessed by population survey 6 weeks later, was self-reported uptake of any clinic service, analysed with random-effects logistic regression. Separately, non-randomised difference-in-differences in monthly ART initiations were analysed for three time periods (6 months baseline; HIVST campaign; 3 months after) at public clinics with (40 clinics) and without (124 clinics) HIVST distribution in catchment area.

findingsA total of 445 conditional-incentive CBDs distributed 39 205 HIVST kits (mean/CBD: 88; 95% CI: 85 to 92) and 447 non-incentive CBDs distributed 41 173 kits (mean/CBD: 93; 95% CI: 89 to 96). Survey participation was 7146/8566 (83.4%), with 3593 (50.3%) reporting self-testing including 1305 (18.3%) previously untested individuals. Use of clinic services post-HIVST was similar in conditional-incentive (1062/3698, 28.7%) and non-incentive (1075/3448, 31.2%) arms (adjusted risk ratio (aRR) 0.94, 95% CI: 0.86 to 1.03). Confirmatory testing by newly diagnosed/untreated HIVST+clients was, however, higher (conditional-incentive: 25/33, 75.8% vs non-incentive: 20/40, 50.0%: aRR: 1.59, 95% CI: 1.05 to 2.39). In total, 12 808 ART initiations occurred, with no baseline or postcampaign differences between initiation rates in HIVST versus non-HIVST clinics, but initiation rates increased from 7.31 to 9.59 initiations per month in HIVST clinics during distribution, aRR: 1.27, 95% CI 1.17 to 1.39.

conclusionsCommunity-based HIVST campaigns achieved high testing uptake, temporally associated with increased demand for ART. Small supply-side incentives did not affect general clinic usage but may have increased confirmatory testing for newly diagnosed HIVST positive participants. TRIAL REGISTRATION NUMBER: PACTR201607001701788.

Indexed as

HIV InfectionsMotivationDelivery of Health CareHumansRural PopulationZimbabweCluster randomised trialcommunity-based surveyepidemiologyHIVpublic health

Identifiers

PMID34275865
PMCPMC8287602
OpenAlexW3183876006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.