ArticleInjury epidemiology2021
A cross sectional study of non-medical use of prescription opioids and suicidal behaviors among adolescents.
Article in Injury epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Opioid Misuse and Suicide-Related Outcomes Among Adolescents and Young Adults: A Systematic Review.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2025Pooled it
- Depression, non-medical pain prescriptions, and suicidal behavior in cancer survivors.Journal of cancer survivorship : research and practice · 2026Article
- Mental health behaviors and suicide risk among White and Black adults with Opioid Use Disorder.Social science & medicine (1982) · 2025Article
- Principal component regression analysis of familial psychiatric histories and suicide risk factors among adults with opioid use disorder.Journal of psychiatric research · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNon-medical use of prescription opioids (NMUPO), defined as taking an opioid in a manner or dose other than prescribed, taking someone else's, or for the feelings that it produces, has been reported by 5 to 20% of adolescents, and is associated with a two fold increase in suicidal behaviors among adolescents. Adolescents with long-term health problems (LTHP) have poorer mental health and may seek NMUPO for pain relief that is not obtained through standard care. For this study, we measured the association between NMUPO and suicidal behaviors, and further assessed effect modification by LTHP hypothesizing the association between NMUPO and suicidal behaviors was stronger for adolescents with LTHP.
findingsFor students with LTHP, 13.5% reported suicide ideation, while 8.0% of students without LTHP reported suicide ideation. For suicide attempt, 4.4% of students with LTHP reported a suicide attempt, while 2.1% of students without LTHP reported a suicide attempt. The proportion of students who reported suicide ideation and attempts increased with higher occasions of NMUPO. Adjusted logistic regression models found increased odds of suicide ideation (OR (95% CI): 1-5 occasions: 2.3 (2.0-2.6); > 6 occasions: 2.7 (2.2-3.8)) and suicide attempts (OR (95% CI): 1-5 occasions: 3.2 (2.7-3.7); > 6 occasions: 4.1 (3.1-5.3)) for students who reported NMUPO. An interaction term for NMUPO and LTHP was then added to the models. Effect modification was not present on the multiplicative scale. On the additive scale, evidence of effect modification was observed: higher risk was indicated for students with LTHP versus no LTHP for both suicide ideation (Predicted risk (95%CI): > 6 occasions NMUPO, LTHP: 0.24 (0.18-0.29); No LTHP: 0.16 (0.13-0.18)) and attempt (Predicted risk (95%CI): 1-5 occasions NMUPO, LTHP: 0.08 (0.07-0.10); No LTHP: 0.05 (0.05-0.06); > 6 occasions NMUPO, LTHP: 0.11 (0.07-0.15); No LTHP: 0.06 (0.05-0.08)).
conclusionsThe results affirmed that NMUPO is associated with suicidal behaviors among adolescents. A pattern also emerged of higher risk of suicidal behaviors for those with LTHP who reported NMUPO. Areas of further inquiry should explore chronic medical or pain conditions as possible modifying pathways that could exacerbate the effects of NMUPO on suicidal behaviors specific to an adolescent population.
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