ArticleLipids in health and disease2021
Association between serum low-density lipoprotein cholesterol and metabolic syndrome in a working population.
Article in Lipids in health and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Evaluation of the effect of baseline predictors on the incidence of metabolic syndrome in middle-aged and elderly individuals: a population-based cohort study in Southwest Iran.Diabetology & metabolic syndrome · 2026Article
- Non-linear relationship between high-density lipoprotein cholesterol and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study in the Japanese population.Frontiers in medicine · 2026Article
- In silico dietary interventions using whole-body metabolic models reveal sex-specific and differential dietary risk profiles for metabolic syndrome.Frontiers in physiology · 2025Article
- Genetic variations of low-density lipoprotein cholesterol on metabolic disorders in obstructive sleep apnea.Nutrition & metabolism · 2024Article
- Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome.Cell reports. Medicine · 2023Article
- Transitioning from having no metabolic abnormality nor obesity to metabolic impairment in a cohort of apparently healthy adults.Cardiovascular diabetology · 2023Article
- Lipid accumulation product is a better predictor of metabolic syndrome in Chinese adolescents: a cross-sectional study.Frontiers in endocrinology · 2023Article
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Abstract
backgroundThe studies, investigating the association of low-density lipoprotein cholesterol (LDL-C) with metabolic syndrome (MetS) are limited with controversial conclusions. Therefore, this study aimed at revealing the specific relationship between the serum LDL-C levels and MetS prevalence in a large working population.
methodsSecondary data analysis of a cross-sectional study, conducted between 2012 and 2016 in Spain on participants aged within the range of 20-70 years, involved 60,799 workers. Logistic regression analysis was applied to evaluate the association between the levels of serum LDL-C and MetS prevalence.
resultsAmong the 60,799 workers, the prevalence of MetS was 9.0%. The odds ratios (95% confidence intervals) of MetS prevalence were 1.27 (1.16-1.39) and 1.53 (1.41-1.65) for the individuals with the LDL-C levels in lower (< 103.8 mg/dL) and upper (> 135.8 mg/dL) tertiles as compared to those with the LDL-C levels in middle tertile (103.8-135.8 mg/dL) in the studied population. Similarly, a U-shaped relationship was also observed in male cohort. The serum LDL-C levels associated with the lowest risk of current MetS were 113.6 mg/dL and 117.6 mg/dL in the overall studied population and male cohort, respectively. The female workers with the levels of LDL-C higher than 135.0 mg/dL had an increased prevalence of MetS (P < 0.05).
conclusionsThe low and high levels of serum LDL-C were associated with an increased prevalence of MetS in the working population and in male workers. Only the high (> 135.0 mg/dL) levels of LDL-C increased MetS prevalence in female workers.
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