Evidence map›Paper›PMID 34275341›Full record

ArticleInnate immunity2021

Synergistic effect of genetic polymorphisms in

Alexander Varzari, Igor V Deyneko, Elena Tudor, Harald Grallert, Thomas Illig

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innate immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Updates on Toll-Like Receptor 10 Research.European journal of immunology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Alexander VarzariLaboratory of Human Genetics, Chiril Draganiuc Institute of Phthisiopneumology, Republic of Moldova.ORCID 0000-0003-1855-3095
Igor V DeynekoLaboratory of Functional Genomics, Timiryazev Institute of Plant Physiology Russian Academy of Sciences, Russia.
Elena TudorLaboratory of Human Genetics, Chiril Draganiuc Institute of Phthisiopneumology, Republic of Moldova.
Harald GrallertResearch Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Germany.
Thomas IlligHannover Unified Biobank, 9177Hannover Medical School, Hannover Medical School, Germany.
Medizinische Hochschule Hannover · DEHelmholtz Zentrum München · DEPhthisiopneumology Institute "Chiril Draganiuc" · MDTimiryazev Institute of Plant Physiology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis (TB). In this study, 14 polymorphisms in 12 key genes involved in the immune response (

Indexed as

GenotypeAdultFemaleGene FrequencyGenetic Association StudiesGenetic LociGenetic Predisposition to DiseaseHumansMaleMiddle AgedMoldovaMycobacterium tuberculosisPolymorphism, Single NucleotidePopulation GroupsRiskToll-Like Receptor 10TLR10 protein, humanTLR6 protein, humanToll-Like Receptor 10Toll-Like Receptor 6Gene polymorphismshost geneticsimmunitypulmonary tuberculosissusceptibility/resistance

Identifiers

PMID34275341
PMCPMC8419295
OpenAlexW3159464706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.