Evidence map›Paper›PMID 34275335›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure.

Hainan Li, Huong Nguyen, Sai Pranathi Meda Venkata, Jia Yi Koh, Anjaneyulu Kowluru, Li Li, Noreen F Rossi, Wei Chen, Jie-Mei Wang

Open access · hybridAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

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  8. Metabolite signaling in the heart.Nature cardiovascular research · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hainan LiDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences (H.L., H.N., S.P.M.V., J.Y.K., A.K., J.-M.W.), Wayne State University, Detroit, MI.
Huong NguyenDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences (H.L., H.N., S.P.M.V., J.Y.K., A.K., J.-M.W.), Wayne State University, Detroit, MI.
Sai Pranathi Meda VenkataDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences (H.L., H.N., S.P.M.V., J.Y.K., A.K., J.-M.W.), Wayne State University, Detroit, MI.
Jia Yi KohDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences (H.L., H.N., S.P.M.V., J.Y.K., A.K., J.-M.W.), Wayne State University, Detroit, MI.
Anjaneyulu KowluruDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences (H.L., H.N., S.P.M.V., J.Y.K., A.K., J.-M.W.), Wayne State University, Detroit, MI.
Li LiDepartments of Internal Medicine (L.L., N.F.R.), Wayne State University, Detroit, MI.
Noreen F RossiDepartments of Internal Medicine (L.L., N.F.R.), Wayne State University, Detroit, MI.
Wei ChenDepartment of Oncology (W.C.), Wayne State University, Detroit, MI.
Jie-Mei WangDepartment of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences (H.L., H.N., S.P.M.V., J.Y.K., A.K., J.-M.W.), Wayne State University, Detroit, MI.
Eugene Applebaum College of Pharmacy and Health Sciences · USWayne State University · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
Role of Ras in Retinal Cell Death in DiabetesR01EY014370 · NEI · WAYNE STATE UNIVERSITY · PI KOWLURU, RENU A. · 2004 to 2023
$4.8M
NADPH Oxidase, Mitochondrial Dysfunction and Diabetic RetinopathyR01EY022230 · NEI · WAYNE STATE UNIVERSITY · PI KOWLURU, ANJANEYULU, KOWLURU, RENU A. · 2012 to 2022
$3.4M
Role of Inositol Requiring Enzyme 1 in Regulating Angiogenesis for Diabetic Wound RepairR01DK109036 · NIDDK · WAYNE STATE UNIVERSITY · PI WANG, JIEMEI · 2016 to 2020
$1.7M
Alleviating Reactive Carbonyl Species-Induced Progenitor Cell Dysfunction in Diabetic Wound HealingR01DK119222 · NIDDK · WAYNE STATE UNIVERSITY · PI MONKS, TERRENCE J., WANG, JIEMEI · 2019 to 2022
$1.5M
Regulation of neuro-cardiovascular function during stressI01BX003480 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI ROSSI, NOREEN F · 2017 to 2021
–
BLRD Research Career Scientist Award ApplicationIK6BX005383 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI Anjaneyulu Kowluru · 2021 to 2026
–
Islet Beta-Cell Dysfunction Under Metabolic StressI01BX004663 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI KOWLURU, ANJANEYULU · 2020 to 2023
–
BLRD VA I01 BX003480BLRD VA I01 BX004663BLRD VA IK6 BX005383NEI NIH HHS R01 EY014370NEI NIH HHS R01 EY022230NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK109036NIDDK NIH HHS R01 DK119222
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsBlood PressureEndothelial CellsEndothelium, VascularHypertensionMiceMice, KnockoutNitric OxidePhosphorylationReceptors, G-Protein-CoupledVasodilationGPR35 protein, mouseNitric OxideReceptors, G-Protein-Coupledblood pressurecardiovascular diseasesGTP cyclohydrolasehomeostasisnitric oxide

Identifiers

PMID34275335
PMCPMC8357038
OpenAlexW3185846648

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.