ArticleEuropean journal of drug metabolism and pharmacokinetics2021
Serum and Synovial Vancomycin Concentrations in Patients with Prosthetic Joint Infection after Intra-articular Infusion.
Article in European journal of drug metabolism and pharmacokinetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Unveiling the landscape of vancomycin in periprosthetic joint infections: a comprehensive bibliometric analysis.Annals of medicine and surgery (2012) · 2026Review
- Monitoring the hematologic markers in patients undergoing single-stage exchange arthroplasty for periprosthetic joint infection.Arthroplasty (London, England) · 2025Article
- Organism profiles and empirical treatments for periprosthetic joint infections.Journal of orthopaedic surgery and research · 2025Article
- Tantalum versus titanium acetabular component in single-stage hip revision for periprosthetic joint infection: a comparative analysis of implant survivorship.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025Article
- High vs. low vancomycin therapeutic concentrations in periprosthetic joint infection: A retrospective cohort analysis.Frontiers in pharmacology · 2025Article
- Local Antibiotic Infusion in Periprosthetic Joint Infection Following Total Hip Arthroplasty.Journal of clinical medicine · 2024Review
- Single-stage revision for chronic periprosthetic joint infection after knee and hip arthroplasties: indications and treatments.Arthroplasty (London, England) · 2023Review
- Therapeutic Drug Monitoring of Vancomycin Concentrations for the Management of Bone and Joint Infections: An Urgent Need.Tropical medicine and infectious disease · 2023Article
- Multiple linear regression model was constructed based on the influencing factors of vancomycin trough concentration.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesVancomycin is one of the most commonly used antibiotics for intra-articular (IA) infusion in the treatment of prosthetic joint infection (PJI). This study aimed to preliminarily investigate the serum and synovial vancomycin concentrations in patients with PJI after IA infusion.
methodsIn total, 16 patients who developed PJI were enrolled in this study; 14 of the patients were treated with IA infusion of vancomycin postoperatively, while the other 2 patients received intravenous (IV) infusion of vancomycin alone. Chemiluminescent immunoassay assay (CLIA) and high-performance liquid chromatography (HPLC) were used to determine the serum and synovial vancomycin concentrations, respectively.
resultsAdministration of vancomycin 0.5 g once daily (qd) IA maintained a high vancomycin trough concentration in synovial fluid before the next IA dose, regardless of whether it was given in combination with IV administration. The combination vancomycin 0.5 g qd IA + vancomycin 1 g every 12 h (q12h) IV yielded relatively good trough concentrations of vancomycin in both serum and synovial fluid. The mean trough serum vancomycin concentration of patients who used vancomycin 1 g q12h IV therapy was above 10 μg/mL; however, no vancomycin was detected in their synovial fluid.
conclusionsThe rational use of IA vancomycin infusion may help to achieve effective therapeutic concentrations of vancomycin in the serum and synovial fluid of patients with PJI.
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