ArticleEnvironmental science and pollution research international2021
Plasma metabolomic profiling in workers with noise-induced hearing loss: a pilot study.
Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- A Systematic Review on Metabolomics Analysis in Hearing Impairment: Is It a Possible Tool in Understanding Auditory Pathologies?International journal of molecular sciences · 2023Pooled it
- Targeting Autophagy for Otoprotection: Translating Basic Mechanisms into Clinical Strategies.International journal of molecular sciences · 2026Review
- A plasma metabolomic fingerprint of moderate or severe hearing loss.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Autophagy in Sensorineural Hearing Loss: Jekyll or Hyde?International journal of molecular sciences · 2026Review
- A Regulator SNP Affecting the Transcription FactorHuman mutation · 2026Article
- Serum homocysteine is a biomarker for hearing loss associated with or without cardiovascular risk: a cross-sectional study in men.European journal of nutrition · 2025Article
- Untargeted plasma metabolite detection in sudden sensorineural hearing loss: identifying key metabolic signatures.Frontiers in molecular biosciences · 2025Article
- Metabolomics and proteomics in occupational medicine: a comprehensive systematic review.Journal of occupational medicine and toxicology (London, England) · 2024Review
- Serum lipid metabolism characteristics and potential biomarkers in patients with unilateral sudden sensorineural hearing loss.Lipids in health and disease · 2024Article
- Review
- [Research progress in genetics of noise-induced hearing loss].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Review
- Dysregulations of metabolites and gut microbes and their associations in rats with noise induced hearing loss.Frontiers in microbiology · 2023Article
- Metabolomic Studies in Inner Ear Pathologies.Metabolites · 2022Review
- Plasma metabolomics analyses highlight the multifaceted effects of noise exposure and the diagnostic power of dysregulated metabolites for noise-induced hearing loss in steel workers.Frontiers in molecular biosciences · 2022Article
- Metabolomics Analysis Reveals Alterations in Cochlear Metabolic Profiling in Mice with Noise-Induced Hearing Loss.BioMed research international · 2022Article
- The role of autophagy and ferroptosis in sensorineural hearing loss.Frontiers in neuroscience · 2022Review
- Metabolomics in Otorhinolaryngology.Frontiers in molecular biosciences · 2022Review
- Diagnostic and predictive values of serum metabolic profiles in sudden sensorineural hearing loss patients.Frontiers in molecular biosciences · 2022Article
- TMT-Based Quantitative Proteomics Reveals Cochlear Protein Profile Alterations in Mice with Noise-Induced Hearing Loss.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noise-induced hearing loss (NIHL) remains a leading occupational related disease and is a serious public health problem. Hence, the identification of potential biomarkers for NIHL prevention and diagnosis has become an urgent work. To discover potential metabolic biomarkers of NIHL, plasma metabolomics analysis in 62 NIHL patients and 62 normal hearing controls was performed using ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF MS). Orthogonal partial least square-discriminant analysis (OPLS-DA) model was applied to distinguish metabolite profile alterations in plasma samples between the two groups. The metabolites with a variable importance of projection (VIP) value > 1 and P value < 0.05 were considered to be potential metabolic biomarkers. KEGG database was performed to explore the involved pathways of potential biomarkers. Three autophagy-related genes (PI3K, AKT, and ATG5) were selected for further verification, and mRNA levels were detected using RT-qPCR analysis. Twenty plasma metabolites with VIP > 1 and P < 0.05 were significantly altered between the two groups. Totally, seven metabolic pathways involving the glycerophospholipid metabolism, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, autophagy pathway, choline metabolism, the alpha-linolenic acid metabolism and linoleic acid metabolism, and retrograde endocannabinoid pathway were significantly related to NIHL. Furthermore, verification by RT-qPCR suggested that the mRNA expression levels of PI3K and AKT along with ATG5 were significantly lower in the NIHL patients compared with controls. In summary, the present study provides the first evidence that the identified aberrantly altered metabolites may be the potentially valuable biomarkers of NIHL for occupational noise-exposed workers. Autophagy signal pathway may be involved in the occurrence and development of NIHL. Moreover, this present study may be helpful to further better understand the metabolic changes in NIHL and be helpful for the understanding of pathogenic mechanism.
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