Evidence map›Paper›PMID 34275061›Full record

Trial reportDigestive diseases and sciences2022

Upper Esophageal Sphincter Compression Device as an Adjunct to Proton Pump Inhibition for Laryngopharyngeal Reflux.

Rena Yadlapati, John E Pandolfino, Madeline Greytak, Jonathon Cahoon, Mary Clarke, Matthew Clary, Daniel Fink, Paul Menard-Katcher, Andrew M Vahabzadeh-Hagh, Philip Weissbrod and 3 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03619811 (Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03619811 nacompletednot on this map

Precision Approach to PPI Therapy in Gastroesophageal Reflux Disease

TypeinterventionalSponsorUniversity of California, San DiegoRan2018 to 2021Enrolled43ConditionsGastroesophageal Reflux, Laryngopharyngeal RefluxArmsReflux Band® Upper Esophageal Sphincter (UES) Assist Device
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Randomized Controlled Trial of Upper Esophageal Sphincter Assist Device in Laryngopharyngeal Reflux Disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
    Trial
  2. Review
  3. Review
  4. Article
  5. [Treatment status and progress of laryngopharyngeal reflux disease].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  6. Review
  7. Review article: Diagnosis and management of laryngopharyngeal reflux.Alimentary pharmacology & therapeutics · 2024
    Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Rena YadlapatiDivision of Gastroenterology, University of California, San Diego School of Medicine, ACTRI Building 1W517, 9500 Gilman Drive MC 0956, La Jolla, CA, 92093, USA. ryadlapati@ucsd.edu.ORCID 0000-0002-7872-2033
John E PandolfinoDivision of Gastroenterology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
Madeline GreytakDivision of Gastroenterology, University of California, San Diego School of Medicine, ACTRI Building 1W517, 9500 Gilman Drive MC 0956, La Jolla, CA, 92093, USA.
Jonathon CahoonDivision of Gastroenterology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Mary ClarkeDivision of Gastroenterology, University of California, San Diego School of Medicine, ACTRI Building 1W517, 9500 Gilman Drive MC 0956, La Jolla, CA, 92093, USA.
Matthew ClaryDivision of Otolaryngology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Daniel FinkDivision of Otolaryngology, Department of Surgery, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Paul Menard-KatcherDivision of Gastroenterology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Andrew M Vahabzadeh-HaghDivision of Otolaryngology, Department of Surgery, University of California San Diego, La Jolla, CA, USA.
Philip WeissbrodDivision of Otolaryngology, Department of Surgery, University of California San Diego, La Jolla, CA, USA.
Samir GuptaDivision of Gastroenterology, University of California, San Diego School of Medicine, ACTRI Building 1W517, 9500 Gilman Drive MC 0956, La Jolla, CA, 92093, USA.
Alexander KaizerDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Sachin WaniDivision of Gastroenterology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
University of California San Diego · USUniversity of Colorado Anschutz Medical Campus · USColorado School of Public Health · USNorthwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
The MVP Trial: A Randomized Controlled Trial of Mechanism Guided vs PPI Strategy for Laryngopharyngeal RefluxR01DK139089 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Rena Hiren Yadlapati · 2024 to 2026
$2.0M
Mechanism Guided Therapy for Laryngopharyngeal RefluxK23DK125266 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YADLAPATI, RENA HIREN · 2021 to 2025
$963k
NCATS NIH HHS UL1 TR001422NIDDK NIH HHS K23 DK125266NIDDK NIH HHS R01 DK139089
6 · The paper itself

Abstract

backgroundThe Reflux Band, an external upper esophageal sphincter (UES) compression device, reduces esophago-pharyngeal reflux events. This study aimed to assess device efficacy as an adjunct to proton pump inhibitor (PPI) therapy in patients with laryngopharyngeal reflux (LPR).

methodsThis two-phase prospective clinical trial enrolled adults with at least 8 weeks of laryngeal symptoms (sore throat, throat clearing, dysphonia) not using PPI therapy at two tertiary care centers over 26 months. Participants used double dose PPI for 4 weeks in Phase 1 and the external UES compression device nightly along with PPI for 4 weeks in Phase 2. Questionnaire scores and salivary pepsin concentration were measured throughout the study. The primary endpoint of symptom response was defined as reflux symptom index (RSI) score ≤ 13 and/or > 50% reduction in RSI.

resultsThirty-one participants completed the study: 52% male, mean age 47.9 years (SD 14.0), and mean body mass index (BMI) 26.2 kg/m

conclusionThis clinical trial highlights the potential efficacy of the external UES compression device (Reflux Band) as an adjunct to PPI for patients with LPR (ClinicalTrials.Gov NCT03619811).

Indexed as

Esophagitis, PepticLaryngopharyngeal RefluxAdultEsophageal Sphincter, UpperFemaleHumansMaleMiddle AgedPepsin AProspective StudiesProton Pump InhibitorsProton PumpsTreatment OutcomePepsin AProton Pump InhibitorsProton PumpsAmbulatory reflux monitoringExtra-esophageal refluxGastroesophageal reflux diseasePeptest

Identifiers

PMID34275061
PMCPMC8286644
OpenAlexW3183240331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.