Evidence map›Paper›PMID 34274990›Full record

ArticleDiabetologia2021

Altered cellular localisation and expression, together with unconventional protein trafficking, of prion protein, PrP

Helmut Hiller, Changjun Yang, Dawn E Beachy, Irina Kusmartseva, Eduardo Candelario-Jalil, Amanda L Posgai, Harry S Nick, Desmond Schatz, Mark A Atkinson, Clive H Wasserfall

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Helmut HillerDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-3277-628X
Changjun YangDepartment of Neuroscience, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-6253-7207
Dawn E BeachyDepartment of Neuroscience, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-3579-7414
Irina KusmartsevaDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-2614-0813
Eduardo Candelario-JalilDepartment of Neuroscience, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-3631-1989
Amanda L PosgaiDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-9491-0958
Harry S NickDepartment of Neuroscience, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-0374-2283
Desmond SchatzDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-1044-5762
Mark A AtkinsonDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8489-4782
Clive H WasserfallDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA. wasserfa@pathology.ufl.edu.ORCID 0000-0002-3522-8932
University of Florida · US

Funding

Single-Cell Analyses of Human Islets in T1D Using Highly Multiplexed ImagingUC4DK108132 · NIDDK · UNIVERSITY OF FLORIDA · PI ATKINSON, MARK A., BODENMILLER, BERND · 2015 to 2015
$3.6M
NIDDK NIH HHS UC4 DK108132
6 · The paper itself

Abstract

aims/hypothesisNormal cellular prion protein (PrP

methodsIn order to evaluate localisation and trafficking of PrP

resultsIn non-diabetic and type 1 diabetic pancreases (the latter displaying both insulin-positive [INS(+)] and -negative [INS(-)] islets), we found PrP CONCLUSIONS/

interpretationAs the first study to address PrP

Indexed as

AdolescentAdultAutoantibodiesCD56 AntigenCell MembraneChildDiabetes Mellitus, Type 1Endoplasmic ReticulumFemaleGene Expression RegulationHeat-Shock ProteinsHumansImmunohistochemistryInsulin AntibodiesMalePancreasAutoantibodiesCD56 AntigenHeat-Shock ProteinsInsulin AntibodiesNCAM1 protein, humanPrion ProteinsPRNP protein, humanPrPC ProteinsRNA, MessengerSTIP1 protein, humanCellular prion proteinProtein traffickingStress-induced phosphoprotein 1Type 1 diabetesType 1 diabetes-dependent endocrine cell expression

Identifiers

PMID34274990
PMCPMC8715394
OpenAlexW3185363452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.