ArticleSexual medicine2021
The Relationship Between Hematologic Parameters and Erectile Dysfunction.
Article in Sexual medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Inflammatory Markers Associated with Antidepressant-Related Side Effects in Patients with Major Depressive Disorder: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Novel predictive factor for erectile dysfunction: systemic immune inflammation index.International journal of impotence research · 2025Article
- Racial differences in hematologic profiles among men with erectile dysfunction: a cross-sectional analysis of NHANES 2001-2004.Translational andrology and urology · 2025Article
- The relationship between complete blood cell count-derived inflammatory biomarkers and erectile dysfunction in the United States.Scientific reports · 2024Article
- Association between inflammation indicators (MLR, NLR, SII, SIRI, and AISI) and erectile dysfunction in US adults: NHANES 2001-2004.Journal of health, population, and nutrition · 2024Article
- The value of PROMs for predicting erectile dysfunction in prostate cancer patients with Bayesian network.Technical innovations & patient support in radiation oncology · 2024Article
- Association between the systemic immune-inflammation index and erectile dysfunction: A cross-sectional study.Immunity, inflammation and disease · 2024Article
- Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study.Scientific reports · 2024Article
- Association between inflammatory indexes and erectile dysfunction in U.S. adults: National Health and Nutrition Examination Survey 2001-2004.Sexual medicine · 2023Article
- Inflammatory biomarkers may predict response to phosphodiesterase type 5 inhibitor treatment in patients with erectile dysfunction.Investigative and clinical urology · 2023Article
- Systematic analysis between inflammation-related index and sex hormones in American adults: cross-sectional research based NHANES 2013-2016.Frontiers in immunology · 2023Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCertain hematologic parameters related to blood cells, known as the biomarkers that predict cardiovascular disease, might be potential predictors of erectile dysfunction (ED) due to the shared pathophysiology between ED and cardiovascular disease .
aimTo investigate the relationship between ED and these hematologic parameters and the clinical significance of hematologic parameters for the diagnosis of ED.
methodsA total of 113 male patients diagnosed with ED were included in this study. Blood samples were collected before 10:00 AM for blood cells examination, biochemical tests, and sex hormone analysis. Another 212 healthy controls without ED from the health management center was included as the control group. The relationship between hematologic parameters and ED was assessed by comparing differences in body mass index (BMI), biochemical indexes and hematologic parameters between the 2 groups, and the diagnostic value of hematologic parameters for ED was also examined and compared.
main outcome measuresInternational Index of Erectile Function, hematologic parameters
resultsThe neutrophil count (NC), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in ED patients were significantly higher than those in healthy controls, whereas the lymphocyte count (LC) was significantly lower than that in healthy controls. After adjusting for age, BMI, uric acid (UA), fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), increases in the NC, NLR, and PLR and a decrease in the LC were shown to be independent risk factors for ED. Receiver operating characteristic (ROC) curve analysis showed that the NLR exhibited better diagnostic performance for ED than the other parameters.
conclusionIncreases in the NC, NLR, and PLR and a decrease in the LC significantly increased the risk of ED. The NC, LC, NLR and PLR could contribute to the diagnosis and assessment of ED. Zhangcheng L, Yuxin T, Xiucheng L and Dongjie L, et al. The Relationship Between Hematologic Parameters and Erectile Dysfunction. Sex Med 2021;9:100401.
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