ArticleEpilepsy & behavior : E&B2021
The impact of processing speed on cognition in temporal lobe epilepsy.
Article in Epilepsy & behavior : E&B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Neuropsychological correlations with fornix and hippocampus in temporal lobe epilepsy demonstrated with diffusion tensor imaging.Epilepsia open · 2026Article
- Multiple subcortical and subcortico-cortico dynamic network reconfigurations characterize focal-to-bilateral tonic-clonic seizures.Scientific reports · 2025Article
- Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy.Journal of neurosurgery · 2025Article
- Comparative analysis of processing speed impairments in TLE, FLE, and GGE: Theoretical insights and clinical Implications.Epilepsy & behavior reports · 2024Review
- The relevance of Spearman'sBrain communications · 2024Article
- Morphological and metabolic asymmetries of the thalamic subregions in temporal lobe epilepsy predict cognitive functions.Scientific reports · 2023Article
- Cognitive Impairment in MRI-Negative Epilepsy: Relationship between Neurophysiological and Neuropsychological Measures.Diagnostics (Basel, Switzerland) · 2023Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo characterize the impact of slowed processing speed on the efficiency of broader cognitive function in temporal lobe epilepsy (TLE).
methodsParticipants included 100 patients with TLE and 89 healthy controls (mean ages 36.8 and 33.6, respectively) administered a neuropsychological battery consisting of 15 cognitive metrics. Confirmatory factor analysis using structural equation modeling (SEM) latent variable modeling demonstrated a cognitive structure representing the domains of verbal intelligence, immediate memory, delayed memory, executive function, working memory, and processing speed. Furthermore, the latent variable measurement model determined the direct and indirect relationships of verbal intelligence and processing speed with immediate memory, delayed memory, executive function, and working memory.
resultsFollowing SEM of hypothesized structural models, the results demonstrated that, among controls, intelligence had a direct and unmediated (by processing speed) relationship with all identified cognitive domains. In contrast, among participants with TLE, processing speed mediated the relationship between verbal intelligence and performance across all cognitive domains.
conclusionSlowing of cognitive/psychomotor processing speed appears to play a critical mediating role in the broader cognitive status of participants with TLE and may serve as a target through which to attempt to exert a broad positive impact on neuropsychological status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.