Evidence map›Paper›PMID 34274511›Full record

ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022

North American Practice-Based Recommendations for Transjugular Intrahepatic Portosystemic Shunts in Portal Hypertension.

Justin R Boike, Bartley G Thornburg, Sumeet K Asrani, Michael B Fallon, Brett E Fortune, Manhal J Izzy, Elizabeth C Verna, Juan G Abraldes, Andrew S Allegretti, Jasmohan S Bajaj and 21 more

Registry-linked trialOpen access · greenAbstract readReviewConsensus Statement
In one paragraph

Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03973372 (Advancing Liver Therapeutic Approaches), which is not on this map. Cited by 118 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 7 pooled it
17.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03973372 active not recruitingnot on this map

Advancing Liver Therapeutic Approaches (ALTA). The ALTA Consortium Study Group for the Management of Portal Hypertension - A 5-year Longitudinal Observational Study of Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt (TIPS) Placement

Typeobservational_patient_registrySponsorUniversity of Texas Southwestern Medical CenterRan2019 to 2027Enrolled852ConditionsCirrhosis, Liver, Transjugular Intrahepatic Portosystemic Shunt (TIPS)
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 7 syntheses or guidelines pooled it, 214 citations in OpenAlex.

  1. Guideline
  2. International Liver Transplantation Society practice guideline update on portopulmonary hypertension.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Guideline
  3. Pooled it
  4. Guideline
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Article
  9. Article
  10. Patients who underwent TIPS face increases in hernia incarceration rates compared to patients managed with paracentesis: An analysis of prevalence and risk factors.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2026
    Article
  11. Review
  12. Article
  13. Reducing the Risk of Overt Hepatic Encephalopathy Recurrence: A Narrative Review.Journal of clinical and translational hepatology · 2026
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. [Research advances on hepatic encephalopathy following transjugular intrahepatic portosystemic shunt].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  19. Article
  20. [A study on the efficacy and safety profile of transjugular intrahepatic portosystemic shunt received elderly patients with liver cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors at 20 institutions in 2 countries.

Justin R BoikeDivision of Gastroenterology and Hepatology, Department of Medicine, Chicago, Illinois.
Bartley G ThornburgDivision of Vascular and Interventional Radiology, Department of Radiology, Chicago, Illinois.
Sumeet K AsraniDivision of Gastroenterology, Department of Medicine, Baylor University Medical Center, Dallas, Texas.
Michael B FallonDivision of Gastroenterology and Hepatology, Department of Medicine, Banner-University Medical Center Phoenix, Phoenix, Arizona.
Brett E FortuneDivision of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medical College, New York, New York.
Manhal J IzzyDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Elizabeth C VernaDivision of Digestive and Liver Diseases, New York, New York.
Juan G AbraldesDivision of Gastroenterology, Liver Unit, University of Alberta, Edmonton, Alberta, Canada.
Andrew S AllegrettiDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Jasmohan S BajajDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Central Virginia Veterans Healthcare System, Richmond, Virginia.
Scott W BigginsDivision of Gastroenterology and Hepatology, Department of Medicine, University of Washington Medical Center, Seattle, Washington.
Michael D DarcyDivision of Interventional Radiology, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Maryjane A FarrDivision of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York.
Khashayar FarsadDotter Department of Interventional Radiology, Portland, Oregon.
Guadalupe Garcia-TsaoDepartment of Digestive Diseases, Veterans Administration-Connecticut Healthcare System, New Haven, Connecticut.
Shelley A HallDivision of Cardiology, Department of Internal Medicine, Dallas, Texas.
Caroline C JadlowiecDivision of Transplant Surgery, Department of Surgery, Mayo Clinic, Phoenix, Arizona.
Michael J KrowkaDivision of Gastroenterology and Hepatology, Department of Pulmonary and Critical Care Medicine, Rochester, Minnesota.
Jeanne LabergeDivision of Interventional Radiology, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Edward W LeeDivision of Interventional Radiology, Department of Radiology, University of California-Los Angeles David Geffen School of Medicine, Los Angeles, California.
David C MulliganDivision of Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
Mitra K NadimDivision of Nephrology and Hypertension, Department of Medicine, University of Southern California, Los Angeles, California.
Patrick G NorthupDivision of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, Virginia.
Riad SalemDivision of Vascular and Interventional Radiology, Department of Radiology, Chicago, Illinois.
Joseph J ShatzelDivision of Hematology and Medical Oncology, Oregon Health and Science University, Portland, Oregon.
Cathryn J ShawDivision of Interventional Radiology, Department of Radiology, Dallas, Texas.
Douglas A SimonettoDivision of Gastroenterology and Hepatology, Department of Physiology, Mayo Clinic, Rochester, Minnesota.
Jonathan SusmanDivision of Interventional Radiology, Department of Radiology, Columbia University Irving Medical Center, New York, New York.
K Pallav KolliDivision of Interventional Radiology, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Lisa B VanWagnerDivision of Gastroenterology and Hepatology, Department of Medicine, Chicago, Illinois; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: lvw@northwestern.edu.
Advancing Liver Therapeutic Approaches (ALTA) Consortium
Dayton Interventional Radiology · USUniversity of California, San Francisco · USBanner - University Medical Center Phoenix · USBaylor University Medical Center · USCenter for Digestive and Liver Diseases · USColumbia University · USColumbia University Irving Medical Center · USCornell University · USMassachusetts General Hospital · USMayo Clinic in Florida · USNorthwestern University · USOregon Health & Science University · USUniversity of Alberta · CAUniversity of California, Los Angeles · USUniversity of Southern California · USUniversity of Virginia · USUniversity of Washington Medical Center · USVA Connecticut Healthcare System · USVanderbilt University Medical Center · USVirginia Commonwealth University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
The Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2M
Evaluating the Safety and Efficacy of Targeting the Contact Pathway to Prevent Device Associated Thrombosis.R01HL151367 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHATZEL, JOSEPH JAMES · 2020 to 2024
$1.5M
Implementation science to improve cardiovascular outcomes among liver transplant recipientsK23HL136891 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VANWAGNER, LISA B · 2017 to 2020
$757k
NCATS NIH HHS UL1 TR001422NCATS NIH HHS UL1 TR001863NHLBI NIH HHS K23 HL136891NHLBI NIH HHS R01 HL151367NIDDK NIH HHS P30 DK132710
6 · The paper itself

Abstract

Complications of portal hypertension, including ascites, gastrointestinal bleeding, hepatic hydrothorax, and hepatic encephalopathy, are associated with significant morbidity and mortality. Despite few high-quality randomized controlled trials to guide therapeutic decisions, transjugular intrahepatic portosystemic shunt (TIPS) creation has emerged as a crucial therapeutic option to treat complications of portal hypertension. In North America, the decision to perform TIPS involves gastroenterologists, hepatologists, and interventional radiologists, but TIPS creation is performed by interventional radiologists. This is in contrast to other parts of the world where TIPS creation is performed primarily by hepatologists. Thus, the successful use of TIPS in North America is dependent on a multidisciplinary approach and technical expertise, so as to optimize outcomes. Recently, new procedural techniques, TIPS stent technology, and indications for TIPS have emerged. As a result, practices and outcomes vary greatly across institutions and significant knowledge gaps exist. In this consensus statement, the Advancing Liver Therapeutic Approaches group critically reviews the application of TIPS in the management of portal hypertension. Advancing Liver Therapeutic Approaches convened a multidisciplinary group of North American experts from hepatology, interventional radiology, transplant surgery, nephrology, cardiology, pulmonology, and hematology to critically review existing literature and develop practice-based recommendations for the use of TIPS in patients with any cause of portal hypertension in terms of candidate selection, procedural best practices and, post-TIPS management; and to develop areas of consensus for TIPS indications and the prevention of complications. Finally, future research directions are identified related to TIPS for the management of portal hypertension.

Indexed as

Esophageal and Gastric VaricesHypertension, PortalPortasystemic Shunt, Transjugular IntrahepaticAscitesGastrointestinal HemorrhageHumansTreatment OutcomeAscitesCirrhosisComplicationsConsensus StatementEnd-Stage Liver DiseaseGuidance DocumentTIPS ProcedureVariceal Bleeding

Identifiers

PMID34274511
PMCPMC8760361
OpenAlexW3186783710

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.