Evidence map›Paper›PMID 34274428›Full record

ArticleToxicology letters2021

Arsenite and monomethylarsonous acid disrupt erythropoiesis through combined effects on differentiation and survival pathways in early erythroid progenitors.

Sebastian Medina, Alicia M Bolt, Xixi Zhou, Guanghua Wan, Huan Xu, Fredine T Lauer, Ke Jian Liu, Scott W Burchiel

Open access · greenAbstract readComparative Study
In one paragraph

Article in Toxicology letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sebastian MedinaThe University of New Mexico College of Pharmacy, Department of Pharmaceutical Sciences, Albuquerque, NM, 87131, USA; New Mexico Highlands University, Department of Biology, Las Vegas, NM, 87701, USA.
Alicia M BoltThe University of New Mexico College of Pharmacy, Department of Pharmaceutical Sciences, Albuquerque, NM, 87131, USA.
Xixi ZhouThe University of New Mexico College of Pharmacy, Department of Pharmaceutical Sciences, Albuquerque, NM, 87131, USA.
Guanghua WanThe University of New Mexico College of Pharmacy, Department of Pharmaceutical Sciences, Albuquerque, NM, 87131, USA.
Huan XuEast China University of Science and Technology, School of Pharmacy, Shanghai, 200237, China.
Fredine T LauerThe University of New Mexico College of Pharmacy, Department of Pharmaceutical Sciences, Albuquerque, NM, 87131, USA.
Ke Jian LiuThe University of New Mexico College of Pharmacy, Department of Pharmaceutical Sciences, Albuquerque, NM, 87131, USA.
Scott W BurchielThe University of New Mexico College of Pharmacy, Department of Pharmaceutical Sciences, Albuquerque, NM, 87131, USA. Electronic address: sburchiel@salud.unm.edu.
University of New Mexico · USEast China University of Science and Technology · CN

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sebastian Medina · 2020 to 2026
$20.4M
UNM Metals Exposure and Toxicity Assessment on tribal Lands in the Southwest (METALS) Superfund Research ProgramP42ES025589 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BOLT, ALICIA M. · 2017 to 2025
$16.4M
Synergistic Immunosuppression by PAHs and ArseniteR01ES019968 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BURCHIEL, SCOTT W · 2012 to 2016
$2.9M
The Role of Biotransformation in Arsenic-Induced HematotoxicityR01ES029369 · NIEHS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, KE JIAN · 2018 to 2022
$1.8M
NCATS NIH HHS UL1 TR001449NIEHS NIH HHS P42 ES025589NIEHS NIH HHS R01 ES019968NIEHS NIH HHS R01 ES029369NIGMS NIH HHS P20 GM130422
6 · The paper itself

Abstract

Strong epidemiological evidence demonstrates an association between chronic arsenic exposure and anemia. We recently found that As

Indexed as

AnemiaAnimalsArsenicArsenitesCell DifferentiationCell SurvivalErythroid Precursor CellsErythropoiesisHumansMiceModels, AnimalOrganometallic CompoundsArsenicArsenitesOrganometallic CompoundsArsenicArsenite (As(+3))ErythropoiesisGATA-1Monomethylarsonous acid (MMA(+3))STAT5

Identifiers

PMID34274428
PMCPMC8487637
OpenAlexW3185212505

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.