Evidence map›Paper›PMID 34274106›Full record

ReviewBiological psychiatry2022

The Neurobiological Effects of Electroconvulsive Therapy Studied Through Magnetic Resonance: What Have We Learned, and Where Do We Go?

Olga Therese Ousdal, Giulio E Brancati, Ute Kessler, Vera Erchinger, Anders M Dale, Christopher Abbott, Leif Oltedal

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biological psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
9.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Olga Therese OusdalMohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway; Centre for Crisis Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway. Electronic address: olgatherese.ousdal@gmail.com.
Giulio E BrancatiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Ute KesslerNORMENT, Division of Psychiatry, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Vera ErchingerMohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Anders M DaleCenter for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, California; Department of Radiology, University of California San Diego, La Jolla, California; Department of Neurosciences, University of California San Diego, La Jolla, California.
Christopher AbbottDepartment of Psychiatry, University of New Mexico, Albuquerque, New Mexico.
Leif OltedalMohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway. Electronic address: leif.oltedal@k1.uib.no.
Haukeland University Hospital · NOUniversity of California San Diego · USUniversity of New Mexico · USUniversity of Pisa · IT

Funding

ECT current amplitude and medial temporal lobe engagementU01MH111826 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2017 to 2019
$1.5M
Electroconvulsive therapy amplitude titration for improved clinical outcomes in late-life depressionR61MH125126 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2021 to 2022
$1.4M
NIMH NIH HHS R61 MH125126NIMH NIH HHS U01 MH111826
6 · The paper itself

Abstract

Electroconvulsive therapy (ECT) is an established treatment choice for severe, treatment-resistant depression, yet its mechanisms of action remain elusive. Magnetic resonance imaging (MRI) of the human brain before and after treatment has been crucial to aid our comprehension of the ECT neurobiological effects. However, to date, a majority of MRI studies have been underpowered and have used heterogeneous patient samples as well as different methodological approaches, altogether causing mixed results and poor clinical translation. Hence, an association between MRI markers and therapeutic response remains to be established. Recently, the availability of large datasets through a global collaboration has provided the statistical power needed to characterize whole-brain structural and functional brain changes after ECT. In addition, MRI technological developments allow new aspects of brain function and structure to be investigated. Finally, more recent studies have also investigated immediate and long-term effects of ECT, which may aid in the separation of the therapeutically relevant effects from epiphenomena. The goal of this review is to outline MRI studies (T1, diffusion-weighted imaging, proton magnetic resonance spectroscopy) of ECT in depression to advance our understanding of the ECT neurobiological effects. Based on the reviewed literature, we suggest a model whereby the neurobiological effects can be understood within a framework of disruption, neuroplasticity, and rewiring of neural circuits. An improved characterization of the neurobiological effects of ECT may increase our understanding of ECT's therapeutic effects, ultimately leading to improved patient care.

Indexed as

Depressive Disorder, Treatment-ResistantElectroconvulsive TherapyBrainHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyAntidepressantBrainDepressionDiffusion-weighted imagingElectroconvulsive therapy (ECT)Magnetic resonance imaging (MRI)Magnetic resonance spectroscopyNeuroimaging

Identifiers

PMID34274106
PMCPMC8630079
OpenAlexW3166627484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.