ArticleThe journal of headache and pain2021
Cortical metabolic and structural differences in patients with chronic migraine. An exploratory
Article in The journal of headache and pain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Headache-related circuits and high frequencies evaluated by EEG, MRI, PET as potential biomarkers to differentiate chronic and episodic migraine: Evidence from a systematic review.The journal of headache and pain · 2022Pooled it
- Brain structural MRI changes before and after 6 months of preventive treatment with erenumab and onabotulinumtoxinA in migraine.The journal of headache and pain · 2026Article
- 5.0 T MRI reveals characteristic alterations in visual and somatomotor networks associated with migraine chronification: a single-center prospective cohort study.The journal of headache and pain · 2025Article
- Heightened visual light sensitivity discomfort measured by the ocular photosensitivity analyzer is associated with chronic ocular pain.The ocular surface · 2025Article
- Cerebral morphometric alterations predict the outcome of migraine diagnosis and subtyping: a radiomics analysis.BMC medical imaging · 2025Article
- Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance.Aging and disease · 2024Review
- Brain connectome-based imaging markers for identifiable signature of migraine with and without aura.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Modifiable factors for migraine prophylaxis: A mendelian randomization analysis.Frontiers in pharmacology · 2023Article
- Association between brain structures and migraine: A bidirectional Mendelian randomization study.Frontiers in neuroscience · 2023Article
- Alterations in metabolic flux in migraine and the translational relevance.The journal of headache and pain · 2022Review
- Behavioral and psychological factors in individuals with migraine without psychiatric comorbidities.The journal of headache and pain · 2022Article
- A preliminary trial of botulinum toxin type A in patients with vestibular migraine: A longitudinal fMRI study.Frontiers in neurology · 2022Article
- Alteration in cerebral cortex thickness and structural covariance networks in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo describe interictal brain structural and metabolic differences between patients with episodic migraine (EM), chronic migraine (CM) and healthy controls (HC).
methodsThis is an exploratory study including right-handed age-matched women with EM, CM and HC. On the same day, a sequential interictal scan was performed with
resultsFifteen patients (8 EM, 7 CM) and 11 HC were included. Morphometric data showed an increased CTh in 6 frontal areas (L/R-Caudal Middle Frontal, L/R-Rostral Middle Frontal, L-Medial Orbitofrontal and L-Superior Frontal) in CM patients compared to HC without differences for IGI. The structural adjusted analysis in CM showed a statistically significantly hypometabolism in 9 frontal areas (L-Lateral Orbitofrontal, L/R-Medial Orbitofrontal, L-Frontal Superior, R-Frontal pole, R-Parts Triangularis, L/R-Paracentral and R-Precentral) and 7 temporal areas (L/R-Insula, L/R-Inferior temporal, L/R-Temporal pole and R-Banks superior temporal sulcus) compared to HC. EM patients presented intermediate metabolic values between EM and HC (non-significant).
conclusionsCM patients showed frontotemporal hypometabolism and increased frontal cortical thickness when compared to HC that may explain some cognitive and behavioural pain-processing and sensory integration alterations in CM patients. Combined information from sequential or simultaneous PET and MRI could optimize the study of complex functional neurological disorders such as migraine.
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