ArticleBMC pregnancy and childbirth2021
Pregnancy complicated with hepatitis B virus infection and preterm birth: a retrospective cohort study.
Article in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 6 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The impact of maternal chronic viral hepatitis infections on pregnancy and neonatal outcomes in in vitro fertilization: a systematic review and meta-analysis.Journal of ovarian research · 2026Pooled it
- Hepatitis B Virus Infection and Risk Factors Among Pregnant Women in Healthcare Facilities in West Africa: A Systematic Review and Meta-Analysis.BioMed research international · 2026Pooled it
- FIGO good practice recommendations on preconception care: A strategy to prevent preterm birth.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Guideline
- Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis.BMC medicine · 2025Pooled it
- [Correlation between hepatitis B virus infection and adverse pregnancy outcomes-a systematic review and meta-analysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024Pooled it
- The effect of hepatitis B virus on the risk of pregnancy outcomes: a systematic review and meta-analysis of cohort studies.Virology journal · 2023Pooled it
- Association between maternal HBV-DNA levels and pregnancy outcomes among hepatitis B carriers: a retrospective cohort study in China.BMC pregnancy and childbirth · 2026Article
- Retrospective analysis of adverse pregnancy outcomes associated with hepatitis B virus infection.BMC pregnancy and childbirth · 2025Article
- Analysis of HBV infection characteristics and OBI prevalence in pregnant women: a focus on HBcAb + alone or in combination with HBeAb + subgroups in Northwest China.BMC infectious diseases · 2025Article
- Geospatial patterns and socioeconomic determinants of the global acute viral hepatitis burden.Frontiers in public health · 2025Article
- Defining knowledge gaps in preterm birth research: Can biomarkers fill the gaps?Frontiers in medicine · 2025Review
- Role of viral hepatitis in pregnancy and its triggering mechanism.Journal of translational internal medicine · 2024Article
- Hepatitis B virus infection, infertility, and assisted reproduction.Journal of Zhejiang University. Science. B · 2024Review
- Differential methylation patterns in paternally imprinted gene promoter regions in sperm from hepatitis B virus infected individuals.BMC molecular and cell biology · 2024Article
- Effects of hepatitis B virus infection and strategies for preventing mother-to-child transmission on maternal and fetal T-cell immunity.Frontiers in immunology · 2023Review
- Association between hepatitis B virus replication during pregnancy and perinatal outcomes: a retrospective cohort study.Annals of medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to investigate whether maternal chronic hepatitis B virus (HBV) infection affects preterm birth (PTB) in pregnant women.
methodsWe retrospectively analyzed HBV-infected and non-infected pregnant women attending antenatal care at Fujian Maternity and Child Health Hospital, Fuzhou, China between January 1, 2016 to December 31, 2018. Participants were divided into HBV infection (n = 1302) and control (n = 12,813) groups. We compared baseline data, pregnancy and perinatal complications, and preterm delivery outcomes between groups. Performed multiple logistics regression analysis to adjust for confounding factors. Finally, we compared early PTB outcome between different HBV DNA level groups.
resultsThe incidence of preterm birth (gestation less than 37 weeks) was similar between the groups, early preterm birth (gestation less than 34 weeks) were significantly more among the HBV infection group than among the controls (1.6% VS. 0.8%; P = 0.003). After adjusting for confounding factors through logistics regression, HBV infection was found to be an independent early PTB risk factor gestation (adjusted odds ratio 1.770; 95% confidence interval [1.046-2.997]). The incidence of early PTB in < 500 group, 500 ~ 2.0 × 10e
conclusionHBV infection is an independent risk factor for early PTB, and the risk did not seem to be influenced by the levels of HBV DNA. Comprehensive programs focusing on pregnant women with HBV infection would reduce the incidence of adverse outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.