ArticlePsychiatry research. Neuroimaging2021
Sex-specific patterns of white matter microstructure are associated with emerging depression during adolescence.
Article in Psychiatry research. Neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies.Brain imaging and behavior · 2023Pooled it
- Identifying neurobiological markers as predictors of antidepressant treatment using diffusion tensor imaging: A tract-based spatial statistical analysis of cingulate bundle.CNS spectrums · 2025Article
- White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions.Depression and anxiety · 2022Article
- A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder.Brain sciences · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Prior research has demonstrated associations between adolescent depression and alterations in the white matter microstructure of fiber tracts implicated in emotion regulation. Using diffusion tensor imaging, this study explored premorbid, sex-specific white matter microstructural features that related to future emergence of major depressive disorder (MDD) during adolescence and young adulthood. Adolescents from the National Consortium on Alcohol and Neurodevelopment in Adolescence study, who were 12-21 years old at study entry and had not experienced major depression as of the baseline assessment, were selected for inclusion (N = 462, n = 223 female adolescents). Over five years of annual follow-up, 63 participants developed a diagnosis of MDD, as determined by the Computerized Semi-Structured Assessment for the Genetics of Alcoholism (n = 39 female adolescents). A whole-brain multivariate modeling approach was used to examine the relationship between fractional anisotropy (FA) at baseline and emergence into MDD, as a function of sex, controlling for age at baseline. Among female adolescents, those who developed MDD had significantly lower baseline FA in a portion of left precentral gyrus white matter, while male adolescents exhibited the opposite pattern. These results may serve as indirect microstructural markers of risk and targets for the prevention of depression during adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.