ArticleCells & development2021
3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo.
Article in Cells & development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A Predictive Model for Coupling Cell Division Orientation to Tissue Mechanics During Epithelial Morphogenesis.bioRxiv : the preprint server for biology · 2026Article
- A predictive model for coupling cell division orientation to tissue mechanics during epithelial morphogenesis.Frontiers in cell and developmental biology · 2026Article
- Mechanical control of cell fate decisions in the skin epidermis.Nature communications · 2025Article
- Dynamic forces drive cell and organ morphology changes during embryonic development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Bioelectric stimulation controls tissue shape and size.Nature communications · 2024Article
- Differences in boundary behavior in the 3D vertex and Voronoi models.PLoS computational biology · 2024Article
- From cells to form: A roadmap to study shape emergence in vivo.Biophysical journal · 2023Review
- Polarized interfacial tension induces collective migration of cells, as a cluster, in a 3D tissue.Biophysical journal · 2022Article
- Linear viscoelastic properties of the vertex model for epithelial tissues.PLoS computational biology · 2022Article
- Dand5 is involved in zebrafish tailbud cell movement.Frontiers in cell and developmental biology · 2022Article
- Understanding laterality disorders and the left-right organizer: Insights from zebrafish.Frontiers in cell and developmental biology · 2022Review
- Sculpting with stem cells: how models of embryo development take shape.Development (Cambridge, England) · 2021Article
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Authors and funding
6 authors.
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Abstract
The left-right organizer in zebrafish embryos, Kupffer's Vesicle (KV), is a simple organ that undergoes programmed asymmetric cell shape changes that are necessary to establish the left-right axis of the embryo. We use simulations and experiments to investigate whether 3D mechanical drag forces generated by the posteriorly-directed motion of the KV through the tailbud tissue are sufficient to drive such shape changes. We develop a fully 3D vertex-like (Voronoi) model for the tissue architecture, and demonstrate that the tissue can generate drag forces and drive cell shape changes. Furthermore, we find that tailbud tissue presents a shear-thinning, viscoelastic behavior consistent with those observed in published experiments. We then perform live imaging experiments and particle image velocimetry analysis to quantify the precise tissue velocity gradients around KV as a function of developmental time. We observe robust velocity gradients around the KV, indicating that mechanical drag forces must be exerted on the KV by the tailbud tissue. We demonstrate that experimentally observed velocity fields are consistent with the viscoelastic response seen in simulations. This work also suggests that 3D viscoelastic drag forces could be a generic mechanism for cell shape change in other biological processes.
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