ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2022
Timing and Type of Early Psychopathology Symptoms Predict Longitudinal Change in Cortical Thickness From Middle Childhood Into Early Adolescence.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Parental Deprivation- and Threat-Based Factors Associated with Youth Emotion-Based Neurocircuitry and Externalizing Behavior: A Systematic Review.Research on child and adolescent psychopathology · 2024Pooled it
- Early psychosocial deprivation alters the refinement of neural dynamics across adolescence.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder.JAMA network open · 2026Article
- Neurostructural Substrates of Hierarchical Dimensions of Internalizing Symptoms in Youth.Human brain mapping · 2026Article
- Association Between Early-life Malnutrition and Lifestyle Behaviors in Later Life Among Rural Elderly with Hypertension - Jia County, Pingdingshan City, Henan Province, China, 2023.China CDC weekly · 2025Article
- Structural Brain Correlates of Anxiety During Development.Current topics in behavioral neurosciences · 2025Review
- Dataset factors associated with age-related changes in brain structure and function in neurodevelopmental conditions.Human brain mapping · 2024Article
- Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Fetal Frontolimbic Connectivity Prospectively Associates With Aggression in Toddlers.Biological psychiatry global open science · 2023Article
- Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development.Nature neuroscience · 2023Article
- Sex and age variations in the impact of puberty on cortical thickness and associations with internalizing symptoms and suicidal ideation in early adolescence.Developmental cognitive neuroscience · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundEarly-life experiences have profound effects on functioning in adulthood. Altered cortical development may be one mechanism through which early-life experiences, including poverty and psychopathology symptoms, affect outcomes. However, there is little prospective research beginning early in development that combines clinician-rated psychopathology symptoms and multiwave magnetic resonance imaging to examine when these relationships emerge.
methodsChildren from the Preschool Depression Study who completed diagnostic interviews at three different developmental stages (preschool, school age, early adolescent) and up to three magnetic resonance imaging scans beginning in middle childhood participated in this study (N = 138). Multilevel models were used to calculate intercepts and slopes of cortical thickness within a priori cortical regions of interest. Linear regressions probed how early-life poverty and psychopathology (depression, anxiety, and externalizing symptoms at separate developmental periods) related to intercept/slope.
resultsCollectively, experiences during the preschool period predicted reduced cortical thickness, via either reduced intercept or accelerated thinning (slope). Early-life poverty predicted intercepts within sensory and sensory-motor integration regions. Beyond poverty, preschool anxiety symptoms predicted intercepts within the insula, subgenual cingulate, and inferior parietal cortex. Preschool externalizing symptoms predicted accelerated thinning within prefrontal and parietal cortices. Depression and anxiety/externalizing symptoms at later ages were not significant predictors.
conclusionsEarly childhood is a critical period of risk; experiences at this developmental stage specifically have the potential for prolonged influence on brain development. Negative early experiences collectively predicted reduced cortical thickness, but the specific neural systems affected aligned with those typically implicated in these individual disorders/experiences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.