Evidence map›Paper›PMID 34273553›Full record

ArticleRespiratory physiology & neurobiology2021

Adenosine A2a receptors modulate TrkB receptor-dependent respiratory plasticity in neonatal rats.

Stephen M Johnson, Ranveer M S Vasdev, McKayla M Miller, Tracy L Baker, Jyoti J Watters

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory physiology & neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Stephen M JohnsonDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States. Electronic address: stephen.m.johnson@wisc.edu.
Ranveer M S VasdevDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States.
McKayla M MillerDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States.
Tracy L BakerDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States.
Jyoti J WattersDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, United States.
University of Wisconsin–Madison · US

Funding

Mechanisms of inactivity-induced respiratory plasticityR01HL105511 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TRACY L · 2011 to 2020
$3.3M
The relationship between sleep apnea and Alzheimer's disease in a unique mouse model: role for microgliaR01HL142752 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TRACY L, WATTERS, JYOTI J · 2019 to 2022
$3.0M
Regulation of microglial plasticity by TLR4 and microRNAsR01NS085226 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI WATTERS, JYOTI J · 2015 to 2019
$1.7M
Short-Term Research Training of Veterinary Students in WisconsinT35OD011078 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI BJORLING, DALE EDMOND, JORGENSEN, JOAN S · 2012 to 2025
$1.0M
NHLBI NIH HHS R01 HL105511NHLBI NIH HHS R01 HL142752NIH HHS T35 OD011078NINDS NIH HHS R01 NS085226
6 · The paper itself

Abstract

Neuroplasticity is a fundamental property of the respiratory control system, enabling critical adaptations in breathing to meet the challenges, but little is known whether neonates express neuroplasticity similar to adults. We tested the hypothesis that, similar to adults, tyrosine receptor kinase B (TrkB) or adenosine A2a receptor activation in neonates are independently sufficient to elicit respiratory motor facilitation, and that co-induction of TrkB and A2a receptor-dependent plasticity undermines respiratory motor facilitation. TrkB receptor activation with 7,8-dihydroxyflavone (DHF) in neonatal brainstem-spinal cord preparations induced a long-lasting increase in respiratory motor output in 55 % of preparations, whereas adenosine A2a receptor activation with CGS21680 only sporadically induced respiratory motor plasticity. CGS21680 and DHF co-application prevented DHF-dependent respiratory motor facilitation, whereas co-application of MSX-3 (adenosine A2a receptor antagonist) and DHF more rapidly induced respiratory motor plasticity. Collectively, these data suggest that mechanisms underlying respiratory neuroplasticity may be only partially operational in early neonatal life, and that adenosine A2a receptor activation undermines TrkB-induced respiratory plasticity.

Indexed as

Respiratory Physiological PhenomenaAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsAnimalsAnimals, NewbornBrain StemDisease Models, AnimalFlavonesNeuronal PlasticityPhenethylaminesRatsReceptor, Adenosine A2AReceptor, trkBSpinal Cord2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine6,7-dihydroxyflavoneAdenosineAdenosine A2 Receptor AgonistsAdenosine A2 Receptor AntagonistsFlavonesPhenethylaminesReceptor, Adenosine A2AReceptor, trkBAdenosine A2a receptorNeonatal ratNeuroplasticityRespiratory controlTrkB receptor

Identifiers

PMID34273553
PMCPMC8484038
OpenAlexW3178693653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.