Evidence map›Paper›PMID 34273464›Full record

ArticleAmerican journal of infection control2021

Treatment with dry hydrogen peroxide accelerates the decay of severe acute syndrome coronavirus-2 on non-porous hard surfaces.

Yan-Jang S Huang, Ashley N Bilyeu, Wei-Wen Hsu, Susan M Hettenbach, Joshua L Willix, Savannah C Stewart, Stephen Higgs, Dana L Vanlandingham

Open access · hybridAbstract read
In one paragraph

Article in American journal of infection control, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yan-Jang S HuangDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS; Biosecurity Research Institute, Kansas State University, Manhattan, KS.
Ashley N BilyeuDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS; Biosecurity Research Institute, Kansas State University, Manhattan, KS.
Wei-Wen HsuDepartment of Statistics, College of Arts and Sciences, Kansas State University, Manhattan, KS.
Susan M HettenbachBiosecurity Research Institute, Kansas State University, Manhattan, KS.
Joshua L WillixDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS; Biosecurity Research Institute, Kansas State University, Manhattan, KS.
Savannah C StewartDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS; Biosecurity Research Institute, Kansas State University, Manhattan, KS.
Stephen HiggsDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS; Biosecurity Research Institute, Kansas State University, Manhattan, KS.
Dana L VanlandinghamDepartment of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS; Biosecurity Research Institute, Kansas State University, Manhattan, KS. Electronic address: dlvanlan@vet.ksu.edu.
Kansas State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDisinfection of contaminated or potentially contaminated surfaces has become an integral part of the mitigation strategies for controlling coronavirus disease 2019. Whilst a broad range of disinfectants are effective in inactivating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), application of disinfectants has a low throughput in areas that receive treatments. Disinfection of large surface areas often involves the use of reactive microbiocidal materials, including ultraviolet germicidal irradiation, chlorine dioxide, and hydrogen peroxide vapor. Albeit these methods are highly effective in inactivating SARS-CoV-2, the deployment of these approaches creates unacceptable health hazards and precludes the treatment of occupied indoor spaces using existing disinfection technologies. In this study, the feasibility of using dry hydrogen peroxide (DHP) in inactivating SARS-CoV-2 on contaminated surfaces in large indoor spaces was evaluated.

methodsGlass slides were inoculated with SARS-CoV-2 and treated with DHP between 5 and 25 ppb for up to 24 hours. Residual infectious virus samples were eluted from three replicates at each time point and titrated in African green monkey VeroE6 cells.

resultsIn comparison with the observed relatively high stability of SARS-CoV-2 on contaminated glass slides (control group), residual infectious titers of glass slides inoculated with SARS-CoV-2 were significantly reduced after receiving 120 minutes of DHP treatment.

conclusionsThe accelerated decay of SARS-CoV-2 on contaminated glass slides suggests that treatment with DHP can be an effective surface disinfection method for occupied indoor spaces.

Indexed as

COVID-19DisinfectantsAnimalsChlorocebus aethiopsDisinfectionHumansHydrogen PeroxideSARS-CoV-2DisinfectantsHydrogen Peroxidedry hydrogen peroxideinactivationsevere acute respiratory syndrome coronavirus-2

Identifiers

PMID34273464
PMCPMC8279916
OpenAlexW3155963608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.