Evidence map›Paper›PMID 34273359›Full record

SynthesisMicrovascular research2021

Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis.

Andrianto, Makhyan Jibril Al-Farabi, Ricardo Adrian Nugraha, Bagas Adhimurda Marsudi, Yusuf Azmi

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Microvascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Endotheliopathy in Acute COVID-19 and Long COVID.International journal of molecular sciences · 2023
    Pooled it
  4. Guideline
  5. Pooled it
  6. Trial
  7. Endotheliitis and cytokine storm as a mechanism of clot formation in COVID-19 ischemic stroke patients: A histopathologic study of retrieved clots.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  8. Article
  9. Article
  10. A Window into the Vascular Endothelium in Covid-19: Nails.Dermatology practical & conceptual · 2025
    Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Review
  16. Observational
  17. Article
  18. Review
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

AndriantoDepartment of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: andrianto@fk.unair.ac.id.
Makhyan Jibril Al-FarabiDepartment of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: m.farabi.17@ucl.ac.uk.
Ricardo Adrian NugrahaDepartment of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: ricardo.adrian.nugraha-2019@fk.unair.ac.id.
Bagas Adhimurda MarsudiDepartment of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Yusuf AzmiFaculty of Medicine, Universitas Airlangga, Surabaya 60286, Indonesia. Electronic address: yusuf.azmi-13@fk.unair.ac.id.
Airlangga University · IDUniversity of Indonesia · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). To better understand the prognostic values of endothelial dysfunction in COVID-19-associated coagulopathy, we conducted a systematic review and meta-analysis to assess biomarkers of endothelial cells in patients with COVID-19.

methodsA literature search was conducted on online databases for observational studies evaluating biomarkers of endothelial dysfunction and composite poor outcomes in COVID-19 patients.

resultsA total of 1187 patients from 17 studies were included in this analysis. The estimated pooled means for von Willebrand Factor (VWF) antigen levels in COVID-19 patients was higher compared to healthy control (306.42 [95% confidence interval (CI) 291.37-321.48], p < 0.001; I

conclusionThe estimated pooled means show increased levels of VWF antigen in COVID-19 patients. Several biomarkers of endothelial dysfunction, including VFW antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19. PROSPERO REGISTRATION NUMBER: CRD42021228821.

Indexed as

AdultAgedAged, 80 and overBiomarkersCOVID-19Endothelium, VascularFemaleHumansMaleMiddle AgedPlasminogen Activator Inhibitor 1Predictive Value of TestsPrognosisThrombomodulinTissue Plasminogen Activatorvon Willebrand FactorBiomarkersPlasminogen Activator Inhibitor 1SERPINE1 protein, humanTHBD protein, humanThrombomodulinTissue Plasminogen Activatorvon Willebrand FactorCOVID-19Endothelial dysfunctionPlasminogen activator inhibitor-1ThrombomodulinTissue-type plasminogen activatorvon Willebrand Factor

Identifiers

PMID34273359
PMCPMC8279939
OpenAlexW3183828749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.