Evidence map›Paper›PMID 34273280›Full record

ArticleCurrent biology : CB2021

Hypothalamic control of interoceptive hunger.

Justin N Siemian, Miguel A Arenivar, Sarah Sarsfield, Yeka Aponte

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
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  7. Brain Cells that Control When We Feel Hungry.Frontiers for young minds · 2025
    Article
  8. Review
  9. Article
  10. Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Sequential Activation of Lateral Hypothalamic Neuronal Populations during Feeding and Their Assembly by Gamma Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  12. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Justin N SiemianNeuronal Circuits and Behavior Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, USA.
Miguel A ArenivarNeuronal Circuits and Behavior Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, USA.
Sarah SarsfieldNeuronal Circuits and Behavior Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, USA.
Yeka AponteNeuronal Circuits and Behavior Unit, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224-6823, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: yeka.aponte@nih.gov.
National Institute on Drug Abuse · USNational Institutes of Health · US

Funding

Hypothalamic neuronal circuits controlling survival behaviorsZIADA000595 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI APONTE, YEKA · 2013 to 2025
$21.3M
Intramural NIH HHS ZIA DA000595
6 · The paper itself

Abstract

While energy balance is critical to survival, many factors influence food intake beyond caloric need or "hunger." Despite this, some neurons that drive feeding in mice are routinely referred to as "hunger neurons," whereas others are not. To understand how specific hypothalamic circuits control interoceptive hunger, we trained mice to discriminate fasted from sated periods. We then manipulated three hypothalamic neuronal populations with well-known effects on feeding while mice performed this task. While activation of ARC

Indexed as

HungerHypothalamusAgouti-Related ProteinAnimalsAppetiteEatingMiceNeuronsAgouti-Related ProteinAgouti-related peptide (AGRP) neuronsarcuate nucleuscompulsivediscriminationfeedinghomeostasishungerinteroceptionlateral hypothalamusreward

Identifiers

PMID34273280
PMCPMC8440483
OpenAlexW3183720841

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.