ArticleDevelopmental cell2021
Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection.
Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Cell fusion after wounding requires plasma membrane damage and endocytosis.bioRxiv : the preprint server for biology · 2026Article
- Harmonic fields and the mechanical response of a cellular monolayer to ablation.Journal of mathematical biology · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Proteases in intestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2026Review
- Rules of life at the interface of calcium signaling and mechanobiology.APL bioengineering · 2025Review
- GαCell communication and signaling : CCS · 2025Article
- Piezo-dependent surveillance of matrix stiffness generates transient cells that repair the basement membrane.Developmental cell · 2025Article
- Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila.Nature communications · 2025Article
- Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila.Nature cell biology · 2024Article
- Dietary Amino Acids Promote Glucagon-like Hormone Release to Generate Novel Calcium Waves in Adipose Tissues.Research square · 2024Article
- After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells.Molecular biology of the cell · 2024Article
- Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10.Insect biochemistry and molecular biology · 2024Article
- After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells.bioRxiv : the preprint server for biology · 2024Article
- Wounding increases nuclear ploidy in wound-proximal epidermal cells of themicroPublication biology · 2024Article
- Live imaging basement membrane assembly under the pupal notum epithelium.microPublication biology · 2024Article
- Article
- Understanding the diversity and dynamics of in vivo efferocytosis: Insights from the fly embryo.Immunological reviews · 2023Review
- A mathematical model of calcium signals around laser-induced epithelial wounds.Molecular biology of the cell · 2023Article
- Article
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9 authors at 1 institution in 1 country.
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Abstract
The presence of a wound triggers surrounding cells to initiate repair mechanisms, but it is not clear how cells initially detect wounds. In epithelial cells, the earliest known wound response, occurring within seconds, is a dramatic increase in cytosolic calcium. Here, we show that wounds in the Drosophila notum trigger cytoplasmic calcium increase by activating extracellular cytokines, Growth-blocking peptides (Gbps), which initiate signaling in surrounding epithelial cells through the G-protein-coupled receptor Methuselah-like 10 (Mthl10). Latent Gbps are present in unwounded tissue and are activated by proteolytic cleavage. Using wing discs, we show that multiple protease families can activate Gbps, suggesting that they act as a generalized protease-detector system. We present experimental and computational evidence that proteases released during wound-induced cell damage and lysis serve as the instructive signal: these proteases liberate Gbp ligands, which bind to Mthl10 receptors on surrounding epithelial cells, and activate downstream release of calcium.
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