ArticleJournal of oral rehabilitation2021
Factors associated with orthodontic pain.
Article in Journal of oral rehabilitation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The association between patients' personality traits and pain perception during orthodontic treatment: a systematic review.Frontiers in neurology · 2024Pooled it
- Pain profile during orthodontic levelling and alignment with fixed appliances reported in randomized trials: a systematic review with meta-analyses.Clinical oral investigations · 2023Pooled it
- Does the pain experienced during orthodontic treatment and bracket removal depend on the architecture of the bracket or debonding method?European journal of orthodontics · 2024Trial
- Review
- Review
- Efficacy of Different Regimens of 980 nm Low-Level Laser Therapy to Reduce Pain Caused by Elastomeric Separator Placement in Adults: A Randomized, Double-Blind, Split-Mouth Placebo-Controlled Study.Journal of clinical medicine · 2026Article
- Salivary and serum chromogranin A as biomarkers of acute stress during early fixed orthodontic treatment: a longitudinal study.Scientific reports · 2026Article
- Palatal miniscrew post-insertion pain: An observational prospective study on consecutively treated patients.Journal of orthodontic science · 2026Article
- Anterior vs. Posterior Bite Raisers: Assessment of Quality of Life and Pain Experience.Children (Basel, Switzerland) · 2025Article
- Pain Perception and Dietary Impact in Fixed Orthodontic Appliances vs. Clear Aligners: An Observational Study.Journal of clinical medicine · 2025Article
- Experimental orthodontic pain drives anxiety state through the induction of alterations to the neuronal architecture in hippocampus.BMC neuroscience · 2025Article
- Assessment of Pain, Diet, and Analgesic Use in Orthodontic Patients: An Observational Study.Medicina (Kaunas, Lithuania) · 2025Observational
- Personality traits, pain perception, and patient attitudes toward orthodontic treatment with fixed appliances.Frontiers in neurology · 2025Article
- Effects of fasudil on glial cell activation induced by tooth movement.Progress in orthodontics · 2024Article
- Effect of acetaminophen on relieving orthodontic pain with clear aligner based on GAD-7: A retrospective research.Heliyon · 2024Article
- Does YouTube provide adequate information about orthodontic pain?The Angle orthodontist · 2023Article
- Pain Relief in Dental Local Anaesthesia with Vibrational Devices: Much Ado about Nothing? A Scoping Review.Journal of clinical medicine · 2023Article
- Factors associated with orthodontic pain.Journal of oral rehabilitation · 2021Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundPain experienced at teeth during orthodontic treatment varies largely over time, with the reasons for its interindividual variability being largely unknown: age, sex, clinical activations, psychosocial factors and genetic polymorphisms of candidate genes are putative factors that may account to explain this variability. We aimed to investigate the effect of clinical, demographic, psychological and genetic factors on pain levels experienced during fixed orthodontic treatment.
methodsA convenience sample of 183 patients undergoing full-fixed orthodontic treatment were recruited. Participant's pain levels were assessed seven times over a three-day period via a smartphone app. Clinical, demographic and psychological data were collected via questionnaires. This included the Pain Catastrophising Scale (Child version), the Corah Dental Anxiety Scale and the State and Trait Anxiety Inventory. Participants provided a DNA sample either in the form of blood or saliva, which were used for genotyping COMT gene rs6269, rs4680, rs4646310, NR3C1 gene rs2963155 and the HTR2A gene rs9316233.
resultsBond ups had the greatest influence on perceived levels of pain experienced on teeth during orthodontic treatment, accounting for over 20% of total variance in pain response. High-pain responders had higher scores on pain catastrophising (magnification subscale). Self-reported pain during fixed orthodontic treatment was not influenced by sex, age, time into treatment, anxiety, nor by polymorphisms of COMT, HTR2A or NR3C1 genes.
conclusionsPain on teeth resulting from orthodontic fixed appliances is stronger during bonds-up and in patients with high catastrophising scores. Demographics, type of clinical activations and the genetic polymorphisms investigated in this research had little or no impact on perceived pain levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.