Evidence map›Paper›PMID 34273067›Full record

SynthesisQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022

The impact of acute pneumococcal disease on health state utility values: a systematic review.

Ryan O'Reilly, Sayako Yokoyama, Justin Boyle, Jeffrey C Kwong, Allison McGeer, Teresa To, Beate Sander

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Health state utilities associated with invasive pneumococcal disease, pneumonia, and recurrent acute otitis media in young children.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Ryan O'ReillyDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. ryan.oreilly@medportal.ca.ORCID http://orcid.org/0000-0003-0844-7352
Sayako YokoyamaPublic Health Ontario, Toronto, ON, Canada.
Justin BoyleTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Jeffrey C KwongDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-7820-2046
Allison McGeerDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Teresa ToDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Beate SanderDalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-2128-9133
University of Toronto · CAUniversity Health Network · CAUniversity of Waterloo · CA

Funding

Canada Research Chairs CRC-950-232429
6 · The paper itself

Abstract

purposeStreptococcus pneumoniae infections remain a significant source of morbidity and mortality worldwide. The purpose of this review was to summarize the impact of pneumococcal disease on health state utilities (HSU) in the acute phase of illness.

methodsWe searched MEDLINE, EMBASE, EconLit, the Health Technology Assessment Database, the National Health Economic Evaluation Database, and Tufts Cost-Effectiveness Registry (up to January 2020) for primary studies. Eligible studies elicited HSU estimates using preference-based instruments for the acute phase of infection of pneumococcal syndromes including acute otitis media, pneumonia/lower respiratory tract infections, bacteremia/sepsis, and meningitis. Two reviewers independently conducted screening, data extraction and quality appraisal.

resultsWe screened 10,178 studies, of which 26 met our inclusion criteria. Cohort sizes ranged from 8 to 2060 respondents. The most frequently studied syndrome was pneumonia (n = 17), followed by acute otitis media (n = 9), meningitis (n = 7) and bacteremia/sepsis (n = 4). Overall, each syndrome was associated with a substantial impact on HSU. Bacteremia/sepsis (range: - 0.331 to 0.992) and meningitis (range: - 0.330 to 0.977) were generally associated with the lowest HSU, followed by pneumonia (range: - 0.054 to 0.998) and acute otitis media (range: 0.064 to 0.970). HSU estimates varied considerably by treatment setting, elicitation method and type of respondent. The only study to compare pneumococcal infections to non-pneumococcal infections in the same population revealed significantly lower HSU estimates among pneumococcal infections.

conclusionsPneumococcal syndromes are associated with decreased HSU estimates. Given the considerable heterogeneity in methods and source populations as well as study quality, care should be taken to select the most appropriate estimates.

Indexed as

Otitis MediaPneumococcal InfectionsCost-Benefit AnalysisHumansInfantQuality of LifeStreptococcus pneumoniaeBacteremiaHealth-related quality of lifeHealth state utilitiesMeningitisOtitis mediaPneumococcal diseasePneumoniaQuality of lifeStreptococcus pneumoniae

Identifiers

PMID34273067
OpenAlexW3178587458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.