ArticleMolecular biology reports2021
Protective effects of Quercetin and Resveratrol on aging markers in kidney under high glucose condition: in vivo and in vitro analysis.
Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Natural Histidine Derivatives-From Basic Research to Potential Applications in Cosmetics and Nutricosmetics.Antioxidants (Basel, Switzerland) · 2026Review
- Cellular senescence of renal tubular epithelial cells in diabetic kidney disease: emerging mechanisms and targeted interventions.Frontiers in cell and developmental biology · 2026Review
- Multi-target regulation of cellular senescence by traditional Chinese medicine: a novel strategy to preventing diabetic kidney disease.Renal failure · 2025Review
- Mechanisms of the Effects of Polyphenols on Diabetic Nephropathy.Current issues in molecular biology · 2025Review
- Characterization of feline nonsteroidal anti-inflammatory drug activated gene-1 (fNAG-1) and its protective function in kidney cells.BMC veterinary research · 2025Article
- Multidimensional mechanisms of quercetin in diabetic kidney disease.Frontiers in cell and developmental biology · 2025Review
- The Role of Renal Cell Senescence in Diabetic Kidney Disease: Mechanisms and Therapeutic Advances.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Podocyte senescence: from molecular mechanisms to therapeutics.Renal failure · 2024Review
- Cellular Senescence: A Bridge Between Diabetes and Microangiopathy.Biomolecules · 2024Review
- The Role of Resveratrol in Aging and Senescence: A Focus on Molecular Mechanisms.Current molecular medicine · 2024Review
- Resveratrol Alleviates Advanced Glycation End-Products-Related Renal Dysfunction in D-Galactose-Induced Aging Mice.Metabolites · 2023Article
- Comparison of Identification and Quantification of Polyphenolic Compounds in Skins and Seeds of Four Grape Varieties.Molecules (Basel, Switzerland) · 2023Article
- The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence.Antioxidants (Basel, Switzerland) · 2022Review
- Identification of Markers for Diagnosis and Treatment of Diabetic Kidney Disease Based on the Ferroptosis and Immune.Oxidative medicine and cellular longevity · 2022Article
- Potential Molecular Mechanisms of Ephedra Herb in the Treatment of Nephrotic Syndrome Based on Network Pharmacology and Molecular Docking.BioMed research international · 2022Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
backgroundResveratrol and Quercetin as powerful herbal antioxidant reduce kidney complications of diabetes. The purpose of this study was to evaluate the protective effects of Quercetin and Resveratrol on aging markers in high glucose condition. METHODS AND
resultsIn this study, HEK-293 cells and kidney tissue of male Wistar rats were used in hyperglycemia condition. Quercetin and Resveratrol for cell culture and in vivo evaluation were used. Amount of methylglyoxal and the gene and protein expression of the Senescence Marker Protein30 (SMP30) were measured using qRT-PCR and ELISA, respectively. High glucose condition in kidney cell and tissue caused increase in glyoxal amount compared to control sample. Treatment with Resveratrol and/or Quercetin significantly decreased the amount of methylglyoxal in a dose-dependent manner. SMP30 expression significantly decreased compare to control group while treatment with Resveratrol and/or Quercetin considerably increased expression level of the protein. Six weeks treatment with Quercetin and Resveratrol had more beneficial effects on aging markers compared with three weeks.
conclusionsAccording to the results, it can be concluded that resveratrol and quercetin, as potent herbal antioxidants, may have significant effects in reducing the complications of diabetes in kidneys, as well as preventing the aging of the kidney cells.
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