Evidence map›Paper›PMID 34273012›Full record

ArticleClinical oral investigations2022

Three-dimensional craniofacial characteristics associated with obstructive sleep apnea severity and treatment outcomes.

Marcela Gurgel, Lucia Cevidanes, Rowdley Pereira, Fabio Costa, Antonio Ruellas, Jonas Bianchi, Paulo Cunali, Lia Bittencourt, Cauby Chaves Junior

Open access · greenAbstract read
In one paragraph

Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Mandibular advancement devices in obstructive sleep apnea: diagnostic predictors for treatment response and clinical implications : A retrospective pilot cohort study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025
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  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Marcela GurgelDepartment of Dental Clinic, School of Dentistry, Federal University of Ceara, 1273 Monsenhor Furtado St, Fortaleza, CE, Brazil. marcela.gurgel@yahoo.com.br.ORCID http://orcid.org/0000-0001-9978-0542
Lucia CevidanesDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Rowdley PereiraDepartment of Pneumology, Division of Sleep Medicine and Biology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Fabio CostaDepartment of Dental Clinic, School of Dentistry, Federal University of Ceara, 1273 Monsenhor Furtado St, Fortaleza, CE, Brazil.
Antonio RuellasDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Jonas BianchiDepartment of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Paulo CunaliDepartment of Pneumology, Division of Sleep Medicine and Biology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Lia BittencourtDepartment of Pneumology, Division of Sleep Medicine and Biology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Cauby Chaves JuniorDepartment of Dental Clinic, School of Dentistry, Federal University of Ceara, 1273 Monsenhor Furtado St, Fortaleza, CE, Brazil.
Universidade Federal de São Paulo · BRUniversidade Federal do Ceará · BRUniversidade Federal do Rio de Janeiro · BRUniversity of Michigan · USUniversity of the Pacific · US

Funding

Quantification of 3D Bony Changes in Temporomandibular Joint OsteoarthritisR01DE024450 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Lucia H Cevidanes · 2013 to 2026
$5.5M
Department of Radiology and Biomedical Imaging, University of California, San Francisco R01DE024450National Institute of Dental and Craniofacial Research (US) R01DE024450NIDCR NIH HHS R01 DE024450
6 · The paper itself

Abstract

objectivesThis study aims to assess craniofacial dimensions in obstructive sleep apnea (OSA) patients treated with a mandibular advancement device (MAD) and to identify anatomic influences on OSA severity and MAD therapy outcomes. MATERIALS AND

methodsTwenty patients with OSA were prospectively treated with MAD. Clinical, cone-beam computed tomography, and polysomnography exams were performed before treatment and 4-6 months after achieving the MAD therapeutic position. Polysomnographic exams and three-dimensional maxillary, mandibular, and upper airway (UA) measurements were evaluated. Pearson's correlation and t-tests were applied.

resultsBefore MAD treatment, the transverse width measured at the frontomaxillary suture and the angle between the mandibular ramus and Frankfurt horizontal were statistically correlated with apnea and the hypopnea index (AHI), while the gonial angle was correlated with therapeutic protrusion. After MAD treatment, all patients showed a significant AHI reduction and an improvement in minimum oxyhemoglobin saturation. The UA total volume, superior and inferior oropharynx volume, and area were statistically correlated with MAD therapeutic protrusion. The UA total area showed a statistical correlation with the improvement in AHI, and the superior oropharynx volume and area increased significantly.

conclusionsThe transversal frontomaxillary suture width and the mandibular ramus facial angle may influence OSA severity. The gonial angle, volume, and area of all UA regions may indicate the amount of protrusion needed for successful MAD treatment. CLINICAL RELEVANCE: The craniofacial characteristics reported as important factors for OSA severity and MAD treatment outcomes impact therapy planning for OSA patients, considering individual anatomic characteristics, prognosis, and cost benefits.

Indexed as

Mandibular AdvancementSleep Apnea, ObstructiveHumansMandiblePolysomnographyTreatment OutcomeAirway managementAnatomyCone-beam computed tomography (CBCT)Mandibular advancement deviceObstructiveOcclusal splintsSleep apnea

Identifiers

PMID34273012
PMCPMC8761785
OpenAlexW3180719316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.