Evidence map›Paper›PMID 34272999›Full record

ArticleParasitology research2021

Antimony resistance associated with persistence of Leishmania (Leishmania) infantum infection in macrophages.

Lucas Sousa Magalhães, Lays Gisele Santos Bomfim, Camilla Natália Oliveira Santos, Priscila Lima Dos Santos, Diego Moura Tanajura, Michael Wheeler Lipscomb, Amélia Ribeiro de Jesus, Roque Pacheco de Almeida, Tatiana Rodrigues de Moura

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Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Lucas Sousa MagalhãesLaboratory of Molecular Biology and Immunology, Federal University of Sergipe, Aracaju, Brazil.
Lays Gisele Santos BomfimHealth Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.
Camilla Natália Oliveira SantosHealth Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.
Priscila Lima Dos SantosHealth Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.
Diego Moura TanajuraDepartment of Health Education, Federal University of Sergipe, Lagarto, Brazil.
Michael Wheeler LipscombDepartment of Biology, Howard University, Washington, D.C., USA.
Amélia Ribeiro de JesusHealth Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.
Roque Pacheco de AlmeidaHealth Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil.
Tatiana Rodrigues de MouraHealth Sciences Graduate Program, Federal University of Sergipe, Aracaju, Brazil. tmoura.ufs@gmail.com.
Universidade Federal de Sergipe · BRInstituto de Medicina Avançada · BRHoward University · US

Funding

Development of tolerogenic dendritic cell-based immunotherapies and restorative insulin approaches to alleviate type 1 diabetesSC1GM127207 · NIGMS · HOWARD UNIVERSITY · PI LIPSCOMB, MICHAEL W · 2018 to 2021
$1.5M
6 · The paper itself

Abstract

Visceral leishmaniasis is a severe disease caused by protozoan parasites that include Leishmania (L.) infantum. The disease is established when parasites subvert the immune response of the host. Notably, chemotherapy-based use of antimonial compounds can partially alleviate disease burden. Unfortunately, the resistance to drug treatments is increasing in areas endemic to the disease. In this report, we investigated immune responses within macrophages infected with antimony-resistant L. infantum isolates from patients with a relapse in the disease. Results revealed that antimony-resistant parasites persist in the first 24 h of infection. Activation of macrophage or blocking of thiol production during infection shows enhanced clearance of parasites, which is coordinately associated with increased production of pro-inflammatory cytokines. Taken together, these results suggest that the mechanism of antimony resistance in L. infantum isolates may be related to a decrease in macrophage microbicidal functions.

Indexed as

AntimonyDrug ResistanceLeishmania infantumHumansLeishmaniasisMacrophagesMeglumine AntimoniateAntimonyMeglumine AntimoniateLeishmania infantumMacrophagesMeglumine antimoniateVisceral leishmaniasis

Identifiers

PMID34272999
OpenAlexW3180982318

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.