Evidence map›Paper›PMID 34272998›Full record

ArticleParasitology research2021

Murine pharmacokinetics and antimalarial pharmacodynamics of dihydroartemisinin trimer self-assembled nanoparticles.

Wenju Guo, Ning Li, Guolian Ren, RongRong Wang, Liqing Chai, Yujie Li, Xi Wang, Qingshan Yang, Ruili Wang, Guoshun Zhang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenju Guo *School of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Ning Li *School of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Guolian RenSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. glren2007@126.com.
RongRong WangSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Liqing ChaiSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Yujie LiSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Xi WangSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Qingshan YangSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Ruili WangSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Guoshun ZhangSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Liuqing YangSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Bofang YiSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China.
Shuqiu ZhangSchool of Pharmacy, Shanxi Medical University, 56 Xinjian South Road, Taiyuan, 030001, Shanxi, China. shuqiu.zhang@sxmu.edu.cn.ORCID http://orcid.org/0000-0001-9741-7969

Funding

Education and Teaching Innovation Project of Shanxi Medical University XJ2018036National Natural Science Foundation of China 81373364Science and Technology Innovation Project of Shanxi Higher School 2017148Startup Foundation for Doctors of Shanxi Medical University 03201619
6 · The paper itself

Abstract

Currently, conjugation of artemisinin-derived dimers, trimers, and tetramers is a viable strategy for developing new effective antimalarial candidates. Furthermore, nanotechnology is an effective means to achieve intravenous administration of hydrophobic drugs. In this paper, an ester-linked dihydroartemisinin trimer (DHA

Indexed as

AntimalarialsArtemisininsNanoparticlesAnimalsArtesunateMalariaMicePlasmodium yoeliiRatsAntimalarialsArtemisininsartenimolArtesunateAntimalarialArtesunateDihydroartemisinin trimerPharmacokineticsSelf-assembled nanoparticles

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.